Evidence map›Paper›PMID 40946168›Full record

ReviewBiophysical journal2025

Integrative functional optical imaging approaches: Optics, microfluidics, and machine learning for neuroscience in organoids and small-animal models.

Jacob M Wheelock, Robert Pritchard, Shiv Kumar, Hang Lu

Abstract readReview
In one paragraph

Review in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Organoids for disease modeling and treatment: state-of-the-art.Experimental hematology & oncology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jacob M WheelockSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia; Interdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, Georgia.
Robert PritchardSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia; Interdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, Georgia.
Shiv KumarSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia.
Hang LuInterdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, Georgia; School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia. Electronic address: hang.lu@gatech.edu.

Funding

Modularly built, complete, coordinate- and template-free brain atlasesR01MH130064 · NIMH · GEORGIA INSTITUTE OF TECHNOLOGY · PI LU, HANG, ZHANG, YUN · 2022 to 2025
$2.6M
Functional Analysis of Whole-Brain Dynamics in LearningR01NS115484 · NINDS · HARVARD UNIVERSITY · PI LU, HANG, ZHANG, YUN · 2020 to 2024
$2.4M
Inferring multi-scale dynamics underlying behavior in aging C. elegansR01AG082039 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI Gordon Joseph Berman, Hang Lu · 2023 to 2026
$2.1M
NIA NIH HHS R01 AG082039NIMH NIH HHS R01 MH130064NINDS NIH HHS R01 NS115484
6 · The paper itself

Abstract

Advances in functional imaging have transformed neuroscience, enabling real-time mapping of neural activity and cellular dynamics. Techniques such as light-sheet microscopy allow whole-brain recordings in model organisms like Caenorhabditis elegans and zebrafish, revealing mechanisms of sensorimotor processing, learning, and neural circuit formation. More recently, the vast complexity of these datasets necessitates machine-learning tools for efficient analysis. Machine-learning-driven approaches improve data quality through denoising, automate segmentation of neurons and tissues, and enable analyses on complex data. By integrating machine learning with advanced imaging, researchers can decode developmental trajectories and neural-network function with unprecedented precision. This review explores the synergy between imaging and computation, highlighting how these innovations drive discoveries in neuroscience.

Indexed as

Machine LearningMicrofluidicsNeurosciencesOptical ImagingOrganoidsAnimalsHumansModels, Animal

Identifiers

PMID40946168
PMCPMC12668823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.