ArticleAnnals of surgical oncology2026
Oxidative Stress Inflammation Score is the Optimal Inflammatory Prognostic Indicator for Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant Immunochemotherapy: A Multicenter Retrospective Cohort Study.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBoth inflammation and oxidative stress significantly affect the occurrence and progression of gastric cancer. In the era of neoadjuvant immunochemotherapy (NICT), the prognostic value of the inflammatory oxidative stress level in patients with locally advanced gastric cancer (LAGC) under new treatment patterns remains to be elucidated.
methodsWe retrospectively collected the medical records of 143 patients with LAGC who underwent radical resection after NICT between 2020 and 2023. Cox regression analysis model was used to evaluate neutrophil count and six oxidative stress factors preoperatively to formulate the oxidative stress inflammation score (OSIS). The correlations between the OSIS and patient survival and recurrence were then assessed. Nonparametric test was used to evaluate the correlation between OSIS and other common inflammatory indicators.
resultsThe OSIS is composed of four preoperative indicators: fibrinogen, albumin, cholesterol, and neutrophil count. Overall survival (OS) and disease-free survival (DFS) were significantly better in the low OSIS group than in the high OSIS group (3-years OS: 88.7% vs. 18.5%, P < 0.001; 3-year DFS: 80.8% vs. 22.2%, P < 0.001) and OSIS was an independent prognostic factor for both OS (hazard ratio = 10.012, P < 0.001), and DFS (hazard ratio = 8.481, P < 0.001). Moreover, OSIS was the strongest predictor compared to other common inflammatory indicators (OS: 0.819, DFS: 0.758).
conclusionsThe OSIS is an effective prognostic indicator for patients with LAGC who undergo radical gastrectomy after NICT, demonstrating excellent predictive power for both survival and recurrence.
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