ArticleNpj mental health research2025
Intron retention: a novel method for evaluating the response to ketamine in patients with treatment-resistant depression.
Article in Npj mental health research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Intron Retention as a Homeostatic State Variable for Drug Response and Recovery: Lessons from Depression for Broader Applications.International journal of molecular sciences · 2026Review
- The IR-Homeostat Hypothesis: Intron Retention as an Evolutionarily Conserved Fine-Tuning Layer and a Reversible Blood Biomarker of Homeostatic Dysregulation in Mood Disorders.International journal of molecular sciences · 2026Review
- Progress and challenges in exploring the pathogenesis of depressive disorders via RNA sequencing.Frontiers in genetics · 2026Review
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Authors and funding
4 authors.
Funding
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Abstract
In response to stress, the body attempts to maintain protein homeostasis through intron retention (IR). By identifying the genes that undergo IR in response to stress, possibly we can identify what type of stress the body is experiencing. Using this principle, we reanalyzed RNA sequencing data of patients with treatment-resistant depression and examined IR genes to investigate their characteristics to ketamine. The ketamine nonresponders were characterized by a state of elevated viral infection. Several IR genes related to viral infection were restored to a healthy state by ketamine, regardless of whether the individual was a nonresponder or a responder. Accordingly, it was more reasonable to describe nonresponders not as individuals for whom ketamine is ineffective but rather as individuals for whom ketamine is insufficient to overcome the extremely elevated inflammatory state of these individuals. This study is pioneering in its exploration of the molecular underpinnings that differentiate between nonresponders and responders.
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Registered trials
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