Evidence map›Paper›PMID 40946103›Full record

ArticleOncogene2025

METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis.

Guglielmo Bove, Mehrad Babaei, Alberto Bueno-Costa, Sajid Amin, Nicla Simonelli, Rosaria Benedetti, Carmela Dell'Aversana, Mariarosaria Conte, Liliana Montella, Vincenzo Summa and 15 more

Abstract read
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Rewriting the RNA code: an mFrontiers in immunology · 2026
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Guglielmo BoveDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Mehrad BabaeiDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Alberto Bueno-CostaCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), IJC Building, Germans Trias I Pujol, Ctra de Can Ruti, Cami de Les Escoles S/N, 08916 Badalona, Barcelona, Catalonia, Spain.
Sajid AminDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Nicla SimonelliDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Rosaria BenedettiDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Carmela Dell'AversanaIEOS-CNR Institute for endocrinology and oncology "Gaetano Salvatore", Via Sergio Pansini 5, Naples, Italy.
Mariarosaria ConteDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Liliana MontellaMedical Oncology Complex Unit, "Santa Maria delle Grazie" Hospital, ASL Napoli 2 Nord, Naples, Italy.
Vincenzo SummaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples "Federico II", Via D. Montesano 49, Naples, Italy.
Margherita BrindisiDepartment of Pharmacy, School of Medicine and Surgery, University of Naples "Federico II", Via D. Montesano 49, Naples, Italy.
Maria Rosaria Del SorboDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Marco CrepaldiDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Gregorio FavaleDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Nuria Profitos-PelejaLymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Vincenzo CarafaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Gaël RouéLymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Fortunato CiardielloDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.ORCID 0000-0002-4661-5540
Annalisa CapuanoDepartemnt of Sperimental Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Hendrik G StunnenbergPrinses Máxima Centrum, Heidelberglaan 25, Utrecht, The Netherlands.ORCID 0000-0002-0066-1576
Wouter L MegchelenbrinkDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.
Angela NebbiosoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.ORCID 0000-0001-5374-3527
Manel Esteller *Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), IJC Building, Germans Trias I Pujol, Ctra de Can Ruti, Cami de Les Escoles S/N, 08916 Badalona, Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.
Lucia Altucci *Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy. lucia.altucci@unicampania.it.ORCID 0000-0002-7312-5387
Nunzio Del Gaudio *Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy. nunzio.delgaudio@unicampania.it.ORCID 0000-0003-3691-443X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N6-methyladenosine (m

Indexed as

Leukemia, Myeloid, AcuteMethyltransferasesProto-Oncogene Proteins c-mycTumor Suppressor ProteinsAdenosineAnimalsApoptosisCell Line, TumorCell ProliferationGene Expression Regulation, LeukemicHumansMiceSignal TransductionAdenosineMethyltransferasesMETTL16 protein, humanMYC protein, humanN-methyladenosineProto-Oncogene Proteins c-mycTumor Suppressor Proteins

Identifiers

PMID40946103
PMCPMC12537489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.