Evidence map›Paper›PMID 40946097›Full record

ArticleNpj mental health research2025

The impact of fine-tuning LLMs on the quality of automated therapy assessed by digital patients.

Stav Yosef, Moreah Zisquit, Ben Cohen, Anat Brunstein Klomek, Kfir Bar, Doron Friedman

Abstract read
In one paragraph

Article in Npj mental health research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. LLMs Can Do Medical Harm: Stress-Testing Clinical Decisions Under Social Pressure.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stav YosefEfi Arazi School of Computer Science, Reichman University, Herzliya, Israel.
Moreah ZisquitBaruch Ivcher School of Psychology, Reichman University, Herzliya, Israel.
Ben CohenEfi Arazi School of Computer Science, Reichman University, Herzliya, Israel.
Anat Brunstein KlomekBaruch Ivcher School of Psychology, Reichman University, Herzliya, Israel.
Kfir Bar *Efi Arazi School of Computer Science, Reichman University, Herzliya, Israel. kfir.bar@runi.ac.il.
Doron Friedman *Sammy Ofer School of Communications, Reichman University, Herzliya, Israel. doronf@runi.ac.il.

Funding

GuestXR 101017884Socrates European Union projects 951930
6 · The paper itself

Abstract

The use of generative large language models (LLMs) in mental health applications is gaining traction, with some proposals even suggesting LLM-based automated therapists. In this study, we assess the impact of fine-tuning therapist LLMs to improve the quality of therapy sessions, addressing a critical question in LLM-based mental health research. Specifically, we demonstrate that fine-tuning with datasets focused on specific therapeutic techniques significantly enhances the performance of LLM therapists. To facilitate this assessment, we introduce a novel evaluation system based on digital patients, powered by LLMs, which engage in text-based therapy sessions and provide session evaluations through questionnaires designed for human patients. This method addresses the inadequacies of traditional text-similarity metrics, which are insufficient for assessing the quality of therapeutic interactions. This study centers on motivational interviewing (MI), a structured and goal-oriented therapeutic approach. However, our digital therapists and patients can be adapted to work in other forms of therapy. We believe that our digital therapists offer a standardized method for assessing automated therapists and showcasing the potential of LLMs in mental health care.

Identifiers

PMID40946097
PMCPMC12433451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.