ArticleNpj mental health research2025
The impact of fine-tuning LLMs on the quality of automated therapy assessed by digital patients.
Article in Npj mental health research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- AI Agents Are Coming: 5-Stage Taxonomy of Language-Based AI Systems for Psychiatry, Psychotherapy, and Counseling.JMIR mental health · 2026Article
- Fine-Tuning Large Language Models for Motivational Interviewing in Health Behavior Change: Development and Evaluation Study.JMIR formative research · 2026Article
- Obedience to Unsafe Clinical Instructions: How Large Language Models Respond to Authority Cues.Research square · 2026Article
- LLMs Can Do Medical Harm: Stress-Testing Clinical Decisions Under Social Pressure.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The use of generative large language models (LLMs) in mental health applications is gaining traction, with some proposals even suggesting LLM-based automated therapists. In this study, we assess the impact of fine-tuning therapist LLMs to improve the quality of therapy sessions, addressing a critical question in LLM-based mental health research. Specifically, we demonstrate that fine-tuning with datasets focused on specific therapeutic techniques significantly enhances the performance of LLM therapists. To facilitate this assessment, we introduce a novel evaluation system based on digital patients, powered by LLMs, which engage in text-based therapy sessions and provide session evaluations through questionnaires designed for human patients. This method addresses the inadequacies of traditional text-similarity metrics, which are insufficient for assessing the quality of therapeutic interactions. This study centers on motivational interviewing (MI), a structured and goal-oriented therapeutic approach. However, our digital therapists and patients can be adapted to work in other forms of therapy. We believe that our digital therapists offer a standardized method for assessing automated therapists and showcasing the potential of LLMs in mental health care.
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Registered trials
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