Evidence map›Paper›PMID 40945866›Full record

ArticleToxicology and applied pharmacology2025

Cardiorespiratory failure and sudden death induced by carfentanil exposure: Involvement of central mu1 opioid receptors.

Xiuping Gao, Jianguo Zhuang, Shan Shi, Zikuan Chen, Fadi Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Carfentanil Depresses Inspiratory Motor Drive.Journal of substance abuse and alcoholism · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiuping GaoDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108, United States of America.
Jianguo ZhuangDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108, United States of America.
Shan ShiDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108, United States of America.
Zikuan ChenDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108, United States of America.
Fadi XuDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108, United States of America. Electronic address: fxu@lrri.org.

Funding

Mechanism and Countermeasure of Fentanyl-Induced Sudden DeathR01HL163512 · NHLBI · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI Fadi Xu · 2023 to 2026
$3.7M
Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and DeathR01DA059063 · NIDA · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI XU, FADI · 2023 to 2025
$2.0M
NHLBI NIH HHS R01 HL163512NIDA NIH HHS R01 DA059063
6 · The paper itself

Abstract

Inhalation of aerosolized carfentanil (CRF) could result in death, but the relevant mechanisms remain unclear. To establish a model of CRF-induced death, we recorded cardiorespiratory activities in rats placed in a double-chamber plethysmograph. CRF exposure (10.0 mg/m

Indexed as

Analgesics, OpioidFentanylReceptors, Opioid, muRespiratory InsufficiencyAnimalsBradycardiaFemaleHeart RateMaleNaloxoneNarcotic AntagonistsRatsRats, Sprague-DawleyAnalgesics, OpioidcarfentanilFentanylNaloxoneNarcotic AntagonistsOprm1 protein, ratReceptors, Opioid, muBradycardiaHypothermiaNaloxoneNaloxone methiodideRespiratory depressionβ-Funaltrexamine and naloxonazine

Identifiers

PMID40945866
PMCPMC12478538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.