Evidence map›Paper›PMID 40945646›Full record

ArticleExperimental neurology2025

Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington's disease.

Qian Wu, Minmin Yao, Hongshuai Liu, Aaron Kakazu, Yuxiao Ouyang, Chang Liu, Ruoxuan Li, Fan Yang, Anqi Wang, Sharmane Surasinghe and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Qian WuDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Minmin YaoDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Hongshuai LiuDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Aaron KakazuDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Yuxiao OuyangDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Chang LiuDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Ruoxuan LiDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Fan YangDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Anqi WangSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sharmane SurasingheDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Damien GerochiDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA.
Barbara BaldoEvotec SE, Manfred Eigen Campus, Hamburg, Germany.
Stefanie JahnEvotec SE, Manfred Eigen Campus, Hamburg, Germany.
Haiying TangCHDI Management for CHDI Foundation, Princeton, NJ, USA.
Hanzhang LuThe Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zhiliang WeiThe Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wenzhen DuanDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of medicine, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: wduan2@jhmi.edu.

Funding

Advanced MRI biomarkers in HD mouse models translatable to humans: nature history and response to therapeuticsR01NS124084 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DUAN, WENZHEN · 2022 to 2025
$2.6M
Pathophysiological mechanisms of hypoperfusion in mouse models of Alzheimer?s disease and small vessel diseaseR01AG081932 · NIA · JOHNS HOPKINS UNIVERSITY · PI Zhiliang Wei · 2023 to 2026
$2.1M
Emerging role of glymphatic clearance in Huntington's diseaseR01NS127344 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Wenzhen Duan, JIadi Xu · 2023 to 2026
$2.0M
Upgrade of the 11.7T Research Scanner at the F.M. Kirby Research CenterS10OD032188 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2024 to 2024
$1.7M
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal modelsR01AG071515 · NIA · JOHNS HOPKINS UNIVERSITY · PI Hanzhang Lu · 2024 to 2026
$1.6M
NIA NIH HHS R01 AG071515NIA NIH HHS R01 AG081932NIH HHS S10 OD032188NINDS NIH HHS R01 NS124084NINDS NIH HHS R01 NS127344
6 · The paper itself

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG-repeat expansion in exon-1 of the huntingtin gene. Currently, no disease-modifying therapies are available, with a significant challenge in evaluating therapeutic efficacy before clinical symptoms emerge. This highlights the need for early biomarkers and intervention strategies. Therefore, it is essential to develop and characterize accurate mouse models and identify early biomarkers for preclinical therapeutic development. In this study, we characterized the pathological progression of the heterozygous zQ175 neodeleted knock in (zQ175DN) mouse model across four age groups: 3, 6, 10, and 16 months to identify human translatable outcome measures. T2-relaxation-under-spin-tagging (TRUST) MRI was used to assess global CMRO

Indexed as

BrainHuntington DiseaseNeurofilament ProteinsOxygenAnimalsDisease Models, AnimalDisease ProgressionFemaleHuntingtin ProteinMagnetic Resonance ImagingMaleMiceMice, TransgenicHuntingtin Proteinneurofilament protein LNeurofilament ProteinsOxygenBrain atrophyCerebral oxygen metabolismHuntington's diseaseMouse modelNeurofilament light chain

Identifiers

PMID40945646
PMCPMC12492807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.