Fc gamma receptor IIa signaling from spinal cord astrocytes promotes neuropathic pain in rats.

Michael J Lacagnina, Kendal F Willcox, Nathan T Fiore, Anamaria R Grieco, Jiahe Li, Cobi J Heijnen, Peter M Grace

Abstract read

In one paragraph

Article in The journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Spinal motor neuron degeneration after brachial plexus avulsion: mechanisms and therapeutic targets.Frontiers in neuroscience · 2026
Review

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael J LacagninaLaboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Kendal F WillcoxLaboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nathan T FioreLaboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Anamaria R GriecoLaboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Jiahe LiLaboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cobi J HeijnenDepartment of Psychological Sciences, Rice University, Houston, TX, USA.

Peter M GraceLaboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: pgrace@mdanderson.org.

Funding

Regulation of Peripheral Neuropathic Pain by B CellsR01NS126252 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Peter M Grace · 2022 to 2026

$2.8M

NINDS NIH HHS R01 NS126252

6 · The paper itself

Abstract

Injury to somatosensory nerves can lead to neuropathic pain. We recently identified that B cells play a crucial role in the development of neuropathic pain through a mechanism involving secreted immunoglobulin G (IgG) signaling at Fc gamma receptors (FcγRs). Here, we demonstrate that Fc gamma receptor IIa (FcγRIIa), expressed by astrocytes in the spinal cord, contributes to the development of mechanical allodynia after nerve injury in male and female rats. Following unilateral chronic constriction injury (CCI) of the sciatic nerve, Fcgr2a gene transcription increased specifically in the ipsilateral dorsal horn of the spinal cord, but remained unaltered in the dorsal root ganglia (DRGs) and contralateral spinal cord. FcγRIIa immunoreactivity increased in the ipsilateral spinal dorsal horn after CCI, and its expression colocalized primarily with GFAP

Indexed as

AstrocytesNeuralgiaReceptors, IgGSignal TransductionSpinal CordAnimalsDisease Models, AnimalFemaleHyperalgesiaImmunoglobulin GMaleRatsRats, Sprague-DawleyImmunoglobulin GReceptors, IgGAstrocyteAutoantibodiesFc gamma receptorNeuroinflammationNeuropathic pain

Identifiers

PMID40945637

DOI10.1016/j.jpain.2025.105553

PMCPMC12445798

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.