Evidence map›Paper›PMID 40945518›Full record

ArticleImmunity2025

Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation.

Guanrui Liao, Tsuguhisa Nakayama, Bokai Zhu, Ivan T Lee, Jason Yeung, Yao Yu Yeo, Yuzhou Chang, Cankun Wang, Steven Chun-Kang Liao, Dingani Nkosi and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Guanrui LiaoCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Tsuguhisa NakayamaDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bokai ZhuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ivan T LeeDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jason YeungCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Yao Yu YeoCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Yuzhou ChangCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Cankun WangDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Steven Chun-Kang LiaoDepartment of Otolaryngology, National Taiwan University Hospital, Yunlin Branch, Yunlin County, Douliu 640203, Taiwan.
Dingani NkosiDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Axel RenteriaDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Dawn T BravoDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jonathan B OverdevestDepartment of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York, NY 10032, USA.
Carol H YanDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
David ZarabandaDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Philip A GallDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sachi S DholakiaDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Nicole A BorchardDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Angela YangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Dayoung KimDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Zara M PatelDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Peter H HwangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Dhananjay WaghDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
John CollerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Katie M PhillipsDepartment of Otolaryngology-Head and Neck Surgery, University of Cincinnati School of Medicine, Cincinnati, OH 45221, USA.
Michael T ChangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Matt LechnerUCL Head and Neck Academic Center, Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.
Zihai LiPelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Te-Huei YehDepartment of Otolaryngology, National Taiwan University Hospital Hsin-Chu Branch, Biomedical Park Hospital, Hsinchu 302058, Taiwan.
Garry NolanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Maria Serena LonghiDepartment of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Vassiliki BoussiotisDepartment of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Dan H BarouchCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Qin MaDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Jayakar V NayakDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Otolaryngology-Head and Neck Surgery, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address: jnayak@stanford.edu.
Sizun JiangCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Dana Farber Cancer Institute, Boston, MA 02115, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: sjiang3@bidmc.harvard.edu.

Funding

Translation Accelerator CoreU19AI171421 · NIAID · STANFORD UNIVERSITY · PI JEFFREY S GLENN · 2022 to 2026
$93.4M
Cancer Immune Monitoring and Analysis CenterU24CA224331 · NCI · DANA-FARBER CANCER INST · PI FRANK S HODI, Catherine Ju-Ying Wu · 2017 to 2026
$18.4M
TriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0M
The Role of the Y Chromosome in Bladder Tumor Development, Growth And ProgressionP01CA278732 · NCI · CEDARS-SINAI MEDICAL CENTER · PI Hany Abdel-Malek Abdel-Hafiz · 2023 to 2026
$10.7M
Project 3: T CellsU54CA260517 · NCI · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2020 to 2024
$10.4M
NHP CoreP01AI177687 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Boris Dominik Juelg · 2023 to 2026
$7.4M
Defining Mechanisms of Viral Persistence in Situ at the Single-Cell LevelR01AI149672 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI ESTES, JACOB D · 2020 to 2024
$4.0M
Optimizing Surgical Transplant of CFTR Gene-Corrected Human Basal Stem Cells to the Upper AirwayR01HL151677 · NHLBI · STANFORD UNIVERSITY · PI NAYAK, JAYAKAR V · 2021 to 2025
$2.4M
Spatial-Temporal Dissection of Stratified Host Tissue Responses to Severe acute respiratory syndrome-related coronaviruses in situ to Understand Intra-host PathogenesisDP2AI171139 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Sizun Jiang · 2022 to 2026
$2.3M
Dissecting Orchestrated Immune Responses to Glioblastoma within the Native Tissue Microenvironment to Improve Treatment OutcomesR01NS139479 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VASSILIKI A BOUSSIOTIS, Alain Charest · 2025 to 2026
$1.4M
Statistical Power Analysis Framework for Multi-Sample and Cross-Platform Spatial Omics ExperimentsR01GM152585 · NIGMS · OHIO STATE UNIVERSITY · PI Dongjun Chung, Qin Ma · 2024 to 2026
$1.2M
SCH: Graph-based Spatial Transcriptomics Computational Methods in Kidney DiseasesR01DK138504 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Michael Thomas Eadon, Qin Ma · 2023 to 2026
$1.1M
NCI NIH HHS P01 CA278732NCI NIH HHS U24 CA224331NCI NIH HHS U54 CA260517NHLBI NIH HHS R01 HL151677NIAID NIH HHS DP2 AI171139NIAID NIH HHS P01 AI177687NIAID NIH HHS R01 AI149672NIAID NIH HHS U19 AI171421NIA NIH HHS U54 AG075931NIDCD NIH HHS K08 DC019956NIDDK NIH HHS R01 DK138504NIGMS NIH HHS R01 GM152585NINDS NIH HHS R01 NS139479
6 · The paper itself

Abstract

Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal cavity affecting millions worldwide. Its complex pathophysiology remains poorly understood, with emerging evidence implicating interactions between diverse immune and epithelial cells in disease progression. We applied single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to both dissociated and intact human tissues from individuals with CRS with and without nasal polyps and compared them with controls. We revealed mechanisms of macrophage-eosinophil recruitment, CD4

Indexed as

Nasal MucosaNasal PolypsRhinitisSinusitisTranscriptomeCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChronic DiseaseEosinophilsEpithelial CellsFemaleGene Expression ProfilingHumansInflammationMacrophagesMaleautoimmunitychronic rhinosinusitisinflammationnasal epitheliumnasal polypremodelingsingle-cellspatial transcriptomicstype 2 inflammation

Identifiers

PMID40945518
PMCPMC12857809

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.