Evidence map›Paper›PMID 40945505›Full record

ArticleMed (New York, N.Y.)2025

A metabolic syndrome: Understanding host factors that drive mortality in tuberculosis meningitis.

Jeffrey M Collins, Russell R Kempker

Abstract readComment
In one paragraph

Article in Med (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jeffrey M CollinsEmory University School of Medicine, Department of Medicine, Division of Infectious Diseases, Atlanta, GA, USA.
Russell R KempkerEmory University School of Medicine, Department of Medicine, Division of Infectious Diseases, Atlanta, GA, USA.

Funding

Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Neel Rajnikant Gandhi · 2022 to 2026
$5.8M
Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
Cavity and Granuloma Oriented Inflammation and Tissue Pharmacokinetics in Pulmonary Tuberculosis (COOK TB)R01AI173946 · NIAID · EMORY UNIVERSITY · PI Russell Ryan Kempker, Brendan Prideaux · 2023 to 2026
$3.1M
Immunometabolic Biomarkers to Advance TB Diagnosis and Treatment MonitoringR01AI182244 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2024 to 2026
$2.2M
High resolution plasma metabolomics to identify biomarkers of tuberculosisK23AI144040 · NIAID · EMORY UNIVERSITY · PI COLLINS, JEFFREY M · 2019 to 2023
$911k
Multiomics Characterization of Micobiome and Immunometabolic REmodeling in Tuberculosis Stress HyperglycemiaR21AI178324 · NIAID · EMORY UNIVERSITY · PI COLLINS, JEFFREY M, MAGEE, MATTHEW JAMES · 2024 to 2025
$423k
FIC NIH HHS D43 TW007124NIAID NIH HHS K23 AI144040NIAID NIH HHS P30 AI168386NIAID NIH HHS R01 AI173946NIAID NIH HHS R01 AI182244NIAID NIH HHS R21 AI178324
6 · The paper itself

Abstract

Cerebrospinal fluid metabolomics uncovered distinct short chain fatty acids and amino acids strongly associated with mortality in persons with tuberculosis meningitis (TBM). These findings from Nhat et al. highlight the critical role of energy metabolism in the host response to TBM and provide new avenues to explore and target for host-directed therapy.

Indexed as

Metabolic SyndromeTuberculosis, MeningealAmino AcidsEnergy MetabolismHumansMetabolomicsAmino Acids

Identifiers

PMID40945505
PMCPMC13126042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.