Evidence map›Paper›PMID 40945382›Full record

ArticleCell calcium2025

Dantrolene normalizes heightened Ca

Navdeep K Uppal, Anthony Valenzuela, Pamela J Lein, Alla F Fomina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Navdeep K UppalDepartment of Physiology & Membrane Biology, School of Medicine, University of California Davis, Davis, CA 95616, USA. Electronic address: nkuppal@ucdavis.edu.
Anthony ValenzuelaDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address: aevalenzuela@ucdavis.edu.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address: pjlein@ucdavis.edu.
Alla F FominaDepartment of Physiology & Membrane Biology, School of Medicine, University of California Davis, Davis, CA 95616, USA. Electronic address: affomina@health.ucdavis.edu.

Funding

Traffic-related air pollution exacerbates AD-relevant phenotypes in a genetically susceptible rat model via neuroinflammatory mechanism(s)R01AG074709 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BEIN, KEITH, LEIN, PAMELA J · 2024 to 2025
$1.7M
NIA NIH HHS R01 AG074709
6 · The paper itself

Abstract

aimDysregulation of the peripheral immune response contributes to Alzheimer's disease pathogenesis. Dantrolene, a negative allosteric modulator of ryanodine receptor types 1 and 3, reduces neurodegeneration in Alzheimer's disease animal models by an unclear mechanism. Given that Alzheimer's disease causative mutations in amyloid precursor and presenilin proteins interfere with intracellular Ca

methodsWe explored cytosolic Ca

resultsWe found no differences in the cytosolic Ca

conclusionsExpression of Alzheimer's disease risk genes upregulates the store-operated Ca

Indexed as

Alzheimer DiseaseCalciumDantroleneLymphocyte ActivationT-LymphocytesAnimalsCalcium SignalingDisease Models, AnimalHumansMaleRatsRats, Inbred F344Rats, TransgenicRyanodine Receptor Calcium Release ChannelCalciumDantroleneRyanodine Receptor Calcium Release ChannelAlzheimer's diseaseCa(2+) influxCaffeineDantroleneLymphocytesMitochondriaRyanodine receptorTgF344-AD rat

Identifiers

PMID40945382
PMCPMC12638002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.