Evidence map›Paper›PMID 40944960›Full record

ArticleJournal of veterinary internal medicine

Multicenter, Retrospective Determination of the Clinical Utility of Screening Tests in Dogs With Immune-Mediated Hemolytic Anemia in the United Kingdom and Ireland.

Tyler Morrison, Ioannis L Oikonomidis, Hannah K Walker, Nuno Sousa Santos, Sophie A Conway, Benoît Cuq, Carolina S C Albuquerque, Claudia Gil-Morales, Glynn Woods

Abstract readMulticenter Study
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tyler MorrisonHospital for Small Animals, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-3432-579X
Ioannis L OikonomidisDepartment of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0002-1591-9891
Hannah K WalkerNorth Downs Specialist Referrals, Bletchingley, UK.
Nuno Sousa SantosWear Referrals Veterinary Hospital, Bradbury, Stockton-on-tees, UK.
Sophie A ConwaySchool of Veterinary Sciences, University of Bristol, Bristol, UK.
Benoît CuqSection of Small Animal Clinical Studies, University College Dublin School of Veterinary Medicine, Dublin, Ireland.ORCID https://orcid.org/0000-0002-7707-3625
Carolina S C AlbuquerqueWear Referrals Veterinary Hospital, Bradbury, Stockton-on-tees, UK.
Claudia Gil-MoralesSchool of Veterinary Sciences, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-6820-5876
Glynn WoodsHospital for Small Animals, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-7801-5697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPotential triggers of immune-mediated hemolytic anemia (IMHA) are often identified, but their frequency and the benefit of extensive screening for these to individual dogs is uncertain.

objectiveTo assess the frequency of non-associative IMHA in dogs undergoing screening in Britain and Ireland and identify where specific tests could be beneficial. ANIMALS: Two hundred twenty-two client-owned dogs with IMHA.

methodsMulticenter, retrospective cohort study of dogs with IMHA. Medical records and blood, urine, imaging, and pathology reports were reviewed. Cases were assessed for associative IMHA, and multivariable analysis was performed to define those.

resultsAssociative IMHA was present in 73/222 (33%) dogs. Diagnoses included toxic (24/222, 11%); infectious (17/222, 8%); neoplastic (16/222, 7%) and non-infectious inflammatory (13/222, 6%) conditions. A further 102 dogs (46%) had a finding most likely incidental, with no pertinent findings in 47/222 (21%) dogs. Associative IMHA was more likely as patients aged (odds ratio 1.108 per year, 95% CI: 1.012-1.218, p = 0.03). CONCLUSIONS AND CLINICAL IMPORTANCE: The benefit of extensive diagnostic screening and implication of detected abnormalities remains uncertain for individual dogs with IMHA in Britain and Ireland. However, older dogs are more likely to have pertinent findings after a diagnosis of IMHA.

Indexed as

Anemia, Hemolytic, AutoimmuneDog DiseasesAnimalsDogsFemaleIrelandMaleRetrospective StudiesUnited Kingdomautoimmunecaninediagnostic imagingIMHAscreening

Identifiers

PMID40944960
PMCPMC12433263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.