ArticleJournal of physiology and biochemistry2025
TRPM8-driven thermogenesis by menthol: mechanisms of cold injury prevention.
Article in Journal of physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Cold injury presents a significant health challenge, causing tissue damage due to prolonged exposure to low temperatures. This study examines menthol's protective effects against cold injury, focusing on its activation of transient receptor potential cation channel subfamily M member 8 (TRPM8), a "cold-sensing" receptor, to stimulate thermogenesis in brown adipose tissue (BAT). Male C57BL/6J mice were treated with menthol for 21 days and exposed to -20 °C. Core body temperature, activity levels, and cold injury severity were measured. Network pharmacology methods identified TRPM8 as a potential target, confirmed through molecular docking and pathway analysis. Further experiments inhibited TRPM8 to evaluate its role in menthol-induced thermogenesis and cold tolerance. Menthol significantly raised core body temperature, improved cold tolerance, and reduced cold injury severity in treated mice. Network pharmacology analysis highlighted TRPM8 as a key regulator of BAT thermogenesis through the PKA/UCP1 pathway. TRPM8 inhibition diminished menthol's effect, underscoring its essential role in menthol-mediated thermogenesis. This study demonstrates that menthol activates TRPM8 in BAT, enhancing thermogenesis to prevent cold injury. These findings suggest menthol as a promising natural agent for cold injury prevention, with TRPM8 as a potential therapeutic target.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.