Evidence map›Paper›PMID 40944814›Full record

Observational studyAIDS and behavior2025

Comparison of Self-Reported Substance Use with Outcomes of Urine Testing among Men Who Have Sex with Men in Africa Participating in HPTN 075.

Theodorus G M Sandfort, Susan H Eshleman, Justin Knox, Autumn Breaud, Katie Weaver, Emily Kerubo, Ravindre Panchia, Erica L Hamilton, Vanessa Cummings, Bill Clarke

Abstract readComparative StudyObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Theodorus G M SandfortDepartment of Psychiatry, HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, 1051 Riverside Dive, Unit 15, New York, NY, 10032, USA. tgs2001@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-4986-1739
Susan H EshlemanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Justin KnoxDepartment of Psychiatry, HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, 1051 Riverside Dive, Unit 15, New York, NY, 10032, USA.
Autumn BreaudDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Katie WeaverDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Emily KeruboKenya Medical Research Institute (KEMRI) CDC, Kisumu, Kenya.
Ravindre PanchiaPerinatal HIV Research Unit, University of the Witwatersrand, Soweto, South Africa.
Erica L HamiltonScience Facilitation Department, Durham, NC, FHI 360, USA.
Vanessa CummingsDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bill ClarkeDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MILTON L WAINBERG · 2003 to 2026
$48.2M
In-depth Understanding of HIV Risk Behavior among Men Who Have Sex With Men in Sub-Saharan Africa: Secondary Analysis of HPTN 075 DataR21MH130217 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI SANDFORT, THEODORUS G.M. · 2022 to 2023
$455k
National Institute of Allergy and Infectious Diseases UM1AI068613National Institute of Allergy and Infectious Diseases UM1AI068617National Institute of Allergy and Infectious Diseases UM1AI068619NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619NIMH NIH HHS P30 MH043520NIMH NIH HHS P30MH43520NIMH NIH HHS R21 MH130217NIMH NIH HHS R21MH130217
6 · The paper itself

Abstract

Research linking substance use with HIV risk behaviors and antiretroviral therapy adherence is typically based on self-reported data. However, studies in high-income countries show that men who have sex with men (MSM) often underreport substance use when compared to objective biological testing. Such comparisons have not been conducted among MSM in sub-Saharan Africa. We compared self-reported and objectively measured substance use among MSM participating in HPTN 075, a multi-site observational cohort study conducted in Kenya, Malawi, and South Africa. Urine samples (n = 734) from 382 participants were tested for the alcohol metabolite ethyl glucuronide and 43 other substances. These tests detect alcohol use in the prior 48-72 h and other substances up to 7 days earlier, depending on the drug. Of the 734 samples, 159 (21.7%) tested positive for ethyl glucuronide. Self-reported alcohol use was available for 97.5% of these cases and confirmed in 141 (91.0%) of them. Sixty samples (8.2%) tested positive for at least one of the 43 other substances. Self-report data were available for 95.0% of those, but use was acknowledged in only 19 (33.3%) cases. These findings suggest that alcohol use is generally reported accurately, while drug use is substantially underreported-likely due to legal prohibitions and social stigma. Incorporating objective substance testing alongside self-reports is recommended to improve the accuracy of substance use measurement in behavioral and clinical HIV research, especially in contexts where stigma or criminalization may inhibit disclosure.

Indexed as

Alcohol DrinkingHIV InfectionsHomosexuality, MaleSelf ReportSubstance Abuse DetectionSubstance-Related DisordersAdultCohort StudiesGlucuronatesHumansMaleMiddle AgedRisk-TakingSouth AfricaYoung Adultethyl glucuronideGlucuronatesMen who have sex with menSub-Saharan AfricaSubstance useUrine testingValidity self-report

Identifiers

PMID40944814
PMCPMC12435900

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.