ReviewMedical oncology (Northwood, London, England)2025
Tumor microenvironment response to neoadjuvant therapy in breast cancer: insights from single-cell and spatial omics.
Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Integrating tumor microenvironment insights into neoadjuvant strategies.Medical oncology (Northwood, London, England) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer remains a significant public health concern, and neoadjuvant therapy has significantly reconfigured the landscape of its clinical management. The intricate characteristics of the tumor microenvironment (TME) have profound implications for tumor development and therapeutic responses. Thus, understanding the dynamics of the TME during treatment is crucial. Advancements in molecular biology research, such as single-cell analysis and spatial omics technologies, provide valuable tools for investigating the complexities of the breast cancer microenvironment. These innovative approaches facilitate the identification of cellular heterogeneity, spatial interactions, and altered signaling pathways, illuminating the TME's adaptive mechanisms in response to neoadjuvant therapy. In this review, we first elucidate the current status of neoadjuvant therapy in breast cancer. Subsequently, we outline cutting-edge molecular biology research methods and their applications within the breast cancer microenvironment. Finally, we provide an overview of the alterations in the components of the tumor microenvironment during neoadjuvant treatment for breast cancer, focusing on insights gained from single-cell analysis and spatial pathology.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.