Evidence map›Paper›PMID 40944786›Full record

ArticleHead and neck pathology2025

Novel BMPR1B::AFF2 in a Sinonasal Region Non-Keratinizing Squamous Cell Carcinoma.

Tyler R Selkin, Varsha Manucha, Jing Xu, Doreen Palsgrove, Julia A Bridge, Justin A Bishop

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tyler R SelkinDepartment of Pathology, University of Texas Southwestern Medical Center, 6201 Harry Hines Blvd., Dallas, TX, 75390, USA.
Varsha ManuchaDepartment of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.
Jing XuDepartment of Pathology, University of Texas Southwestern Medical Center, 6201 Harry Hines Blvd., Dallas, TX, 75390, USA.
Doreen PalsgroveDepartment of Pathology, University of Texas Southwestern Medical Center, 6201 Harry Hines Blvd., Dallas, TX, 75390, USA.
Julia A BridgeDepartment of Pathology, University of Utah and ARUP Laboratories, Salt Lake City, UT, USA.
Justin A BishopDepartment of Pathology, University of Texas Southwestern Medical Center, 6201 Harry Hines Blvd., Dallas, TX, 75390, USA. Justin.A.Bishop@UTSouthwestern.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMolecular diagnostic tools may help resolve difficult differential diagnoses, and in some cases, they uncover entirely novel findings.

methodsWe performed immunohistochemistry and molecular analysis on a cytologically bland squamous tumor of the sinonasal region.

resultsWe found a previously unreported BMPR1B::AFF2 fusion in a difficult-to-characterize nasal and nasopharyngeal tumor exhibiting aggressive local behavior and recurrence.

conclusionWhile the DEK::AFF2 fusion is well-characterized in sinonasal region tumors, alternate fusion partners are becoming increasingly recognized.

Indexed as

Bone Morphogenetic Protein Receptors, Type ICarcinoma, Squamous CellParanasal Sinus NeoplasmsSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorHumansOncogene Proteins, FusionBiomarkers, TumorBone Morphogenetic Protein Receptors, Type IOncogene Proteins, FusionDEK::AFF2Fluorescence in situ hybridizationPapillary squamous cell carcinomaSinonasal tumors

Identifiers

PMID40944786
PMCPMC12433389

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.