ReviewJournal of molecular neuroscience : MN2025
Exploring Ciliary Mechanisms in the Causation of Hydrocephalus in Humans-Similarities and Differences from Animal Models.
Review in Journal of molecular neuroscience : MN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis.Brain : a journal of neurology · 2026Article
- Exome sequencing-based identification ofFrontiers in molecular biosciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Hydrocephalus is a condition defined by excessive cerebrospinal fluid (CSF) relative to the brain volume. Congenital and infantile forms of hydrocephalus are both genetically and physiologically heterogenous. Among the candidate genes implicated in hydrocephalus, many are associated with cilia, a subcellular structure involved in CSF circulation and neurodevelopment. First, we provide an overview of 129 genes associated with human hydrocephalus and currently reported in the literature, categorized according to their possible involvement in ciliary structure, ciliary function, or cilia-mediated processes/signalling pathways. Intriguingly, there are large differences in the prevalence and manifestations of cilia-related hydrocephalus in humans as compared to rodents. Second, we address these differences by revisiting human and animal studies to outline potential cilia-related mechanisms and molecular signalling pathways contributing to hydrocephalus. We propose that our rapidly expanding understanding of cilia's role in CSF circulation and brain development will support a more precise characterization of hydrocephalus subtypes, ultimately guiding the development of more personalized treatment strategies.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.