ArticleSurgery today2026
Induction chemotherapy followed by long-course chemoradiotherapy versus short-course radiotherapy followed by consolidation chemotherapy for achieving complete response in patients with locally advanced rectal cancer: a propensity-score matching study.
Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cytotoxic immune activity reflects a coordinated immune microenvironment and is associated with response to total neoadjuvant therapy in rectal cancer.Journal of gastroenterology · 2026Article
- Preoperative prealbumin levels are prognostic predictors of overall survival, independent of inflammation severity, in patients with gastric cancer following gastrectomy.Surgery today · 2026Article
- Prognostic discrepancies between surgery-first and neoadjuvant-treated resected pancreatic cancer in the same pathological stage.Surgery today · 2026Article
- Low preoperative prealbumin increases non-gastric cancer mortality in patients with early or advanced gastric cancer after gastrectomy: a retrospective cohort study.Surgery today · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
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Abstract
purposeThis study compared complete response (CR) outcomes between two total neoadjuvant therapy (TNT) strategies for locally advanced rectal cancer: induction chemotherapy followed by long-course chemoradiotherapy (INCT-LCCRT) versus short-course radiotherapy followed by consolidation chemotherapy (SCRT-CNCT).
methodsThe subjects of this retrospective study were 234 patients with clinical stage T3-4NanyM0 low rectal cancer, treated between 2011 and 2022 with TNT and either total mesorectal excision or non-operative management (NOM). CR was defined as pathological CR after resection or sustained clinical CR in NOM. Propensity score matching was applied to adjust baseline differences, resulting in 38 matched pairs. We evaluated CR rates and survival outcomes.
resultsThere were 194 patients treated with INCT-LCCRT and 40 treated with SCRT-CNCT. The INCT-LCCRT group had more advanced disease features, including higher rates of clinical T4 (29.9% vs. 2.5%) and lateral pelvic node metastases (62.4% vs. 10%). The CR rates were comparable in the full cohort (30.9% vs. 30.0%, p = 1) and after matching (34.2% vs. 28.9%, p = 0.81). No significant differences were observed in 3-year relapse-free or local recurrence-free survival.
conclusionsIn the matched cohort of mainly intermediate-risk cases, INCT-LCCRT and SCRT-CNCT demonstrated comparable CR rates and oncological outcomes.
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