Evidence map›Paper›PMID 40944737›Full record

GuidelineSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

MASCC/ISOO Clinical Practice Statement: imaging and clinical laboratory tests in the diagnosis and management of medication-related osteonecrosis of the jaw.

Noam Yarom, Ragda Abdalla-Aslan, Cesar Migliorati, Elena Livshits, Mohammed Amir Rais, Wonse Park, Eduardo R Fregnani, Kivanc Bektas-Kayhan, Joel Epstein, Sharon Elad

Abstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noam YaromOral Medicine Unit, Sheba Medical Center, Tel Hashomer, 5265601, Israel. noam.yarom@sheba.health.gov.il.
Ragda Abdalla-AslanThe Department of Oral and Maxillofacial Surgery, Rambam Health Care Campus, Haifa, Israel.
Cesar MiglioratiOral and Maxillofacial Diagnostic Sciences, Oral Medicine, University of Florida College of Dentistry, Gainesville, FL, USA.
Elena LivshitsOral Medicine Unit, Sheba Medical Center, Tel Hashomer, 5265601, Israel.
Mohammed Amir RaisOral & Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA.
Wonse ParkDepartment of Advanced General Dentistry, Yonsei University College of Dentistry, Seoul, Korea.
Eduardo R FregnaniCentro de Oncologia Molecular, Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, SP, Brazil.
Kivanc Bektas-KayhanDepartment of Oral and Maxillofacial Surgery, İstanbul University Faculty of Dentistry, Istanbul, Turkey.
Joel EpsteinDental Oncology Services, City of Hope National Medical Center, Duarte, CA, USA.
Sharon EladOral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise resource for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS focuses on the use of imaging and clinical laboratory tests for the diagnosis, staging, monitoring, treatment decision, and prediction of medication-related osteonecrosis of the jaw (MRONJ) in cancer patients.

methodsThis CPS was developed based on a critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of the Oral Care Study Group (OCSG) of MASCC/ISOO. The information is presented in the form of succinct bullets and tables to generate a short manual about the best standard of care.

resultsRadiographs, cone beam computerized tomography (CT), conventional CT, magnetic resonance imaging (MRI), and nuclear imaging are often utilized in patients with MRONJ. The CPS describes the considerations for selecting each imaging modality. Laboratory workup in patients with MRONJ is often derived by comorbidities, with immune status and bleeding tendency being the key considerations.

conclusionImaging and lab tests have an important role in the diagnosis and management of MRONJ. The imaging modality and specific laboratory tests should be tailored to the patient's needs.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawClinical Laboratory TechniquesHumansMagnetic Resonance ImagingNeoplasmsBisphosphonatesBlood testsBone-modifying agentsBone turnover markersDenosumabImagingOsteonecrosis of the jawRadiographs

Identifiers

PMID40944737
PMCPMC12433361

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