Evidence map›Paper›PMID 40944722›Full record

Observational studyEuropean journal of nuclear medicine and molecular imaging2026

Detection rate of FDG-PET/CT for occult cancer in patients with cryptogenic ischemic stroke.

Carmen García-Cabo, Lorena Benavente, Beatriz Del Amor, Carmen Vigil, Sara Naranjo Sancho, María Rico, Montserrat González, Davinia Larrosa, María Castañón, Elena López-Cancio and 2 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carmen García-CaboNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain. c.garciacabo@gmail.com.ORCID 0000-0003-1273-0396
Lorena BenaventeNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.
Beatriz Del AmorNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.
Carmen VigilNuclear Medicine Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Sara Naranjo SanchoNuclear Medicine Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
María RicoNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.
Montserrat GonzálezNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.
Davinia LarrosaNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.
María CastañónNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.
Elena López-CancioNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.
Gemma González VelascoNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.
Sergio CallejaNeurology Department, Hospital Universitario Central de Asturias, Avenida de Roma SN. 33011, Oviedo, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCryptogenic stroke represents a third of ischemic strokes and has a significant recurrence rate. Occult cancer has been Identified as a causal factor in up to 5-10% of this type of strokes. We propose that a whole body FDG-PET/CT may increase the detection rate of occult cancer diagnosis in patients with cryptogenic stroke. PATIENTS AND

methodsObservational prospective study including patients with cryptogenic ischemic stroke who underwent an FDG-PET/CT scan. Clinical, radiological (three territory sign) and specific analytical measurements (D-dimer) were also informed.

resultsA total of 140 patients were included in the study, with a mean age of 71. The PET scan showed abnormalities in 30% of patients with cryptogenic stroke, with a confirmed cancer diagnosis in 18%. Elevated D-dimer levels and a higher OCCULT-5 score were associated with occult cancer.

conclusionsOccult cancer was found in 18% of cryptogenic stroke cases in our study, evidenced by whole body FDF-PET/CT scans, which results in significant therapeutic and prognostic implications. Some imaging and analytical determinations seem to have potential for the selection of eligible patients for more advanced examinations.

Indexed as

Fluorodeoxyglucose F18Ischemic StrokePositron Emission Tomography Computed TomographyAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsCryptogenic strokePETStroke diagnosis

Identifiers

PMID40944722

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.