ArticleJournal of the American Chemical Society2025
A Complete Mechanistic Framework for Molecular Glue Characterization.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- A Versatile DNA-Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design.Journal of chemical information and modeling · 2026Article
- Construction of an Immunosensor Based on the Affinity DNA Functional Ligands to the Fc Segment of IgG Antibody.Biosensors · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of molecular glues to modulate protein-protein interactions has emerged as a promising approach to drug previously intractable targets. Despite strong interest in this modality, a comprehensive theoretical framework is lacking. We have established a complete mechanistic analysis which enables the determination of molecular glues' binding and cooperativity values from a simple biochemical matrix experiment. We validated the model using numerical integration and experimental data from fluorescence resonance energy transfer and fluorescence polarization assays. As the derived models enable the determination of all thermodynamic parameters of any molecular glue, they have significant applications in drug discovery, particularly for molecular glue optimization and characterization of neo-substrates.
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Registered trials
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