Evidence map›Paper›PMID 40944639›Full record

ArticleACS chemical neuroscience2025

Serotonin 5-HT

Emma M Bonniwell, Rana Alabdali, Joseph J Hennessey, John L McKee, Natalie G Cavalco, Josie C Lammers, Ethan J Moore, Luca Franchini, Cesare Orlandi, John D McCorvy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. The Effect of Serotonin 5-HTAddiction biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emma M BonniwellDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0001-5743-852X
Rana AlabdaliDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, United States.
Joseph J HennesseyDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0003-0981-4695
John L McKeeDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0009-0003-7988-8646
Natalie G CavalcoDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0009-0001-0774-717X
Josie C LammersDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0009-0006-3499-1481
Ethan J MooreDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, United States.
Luca FranchiniDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, United States.
Cesare OrlandiDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, United States.ORCID 0000-0002-4992-9350
John D McCorvyDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0001-7555-9413

Funding

Molecular Mechanisms of G protein-coupled Receptor Biased SignalingR35GM133421 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI John D McCorvy · 2019 to 2026
$3.3M
Discovery of synthetic and endogenous ligands for orphan GPCR GPR156R01DC022104 · NIDCD · UNIVERSITY OF ROCHESTER · PI Cesare Orlandi · 2024 to 2026
$2.0M
Investigations into 5-HT2A signaling mechanisms of psychedelic drugs for the treatment of stimulant use disorderR01DA061433 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI ADAM L. Halberstadt, John D McCorvy · 2024 to 2026
$1.5M
NIDA NIH HHS R01 DA061433NIDCD NIH HHS R01 DC022104NIGMS NIH HHS R35 GM133421
6 · The paper itself

Abstract

The serotonin 2C receptor (5-HT

Indexed as

HallucinogensReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsSignal TransductionAnimalsbeta-Arrestin 2HEK293 CellsHumansbeta-Arrestin 2HallucinogensReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Agonists5-HT2C receptorbiased agonismGPCRG proteinpsychedelicsserotonin

Identifiers

PMID40944639
PMCPMC12629614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.