ArticleHuman brain mapping2025
Trauma Timing and Its Impact on Brain Activation During Flexible Emotion Regulation in PTSD: Insights From Functional MRI.
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional brain alterations associated with acupuncture for chronic pain: a scoping review of fMRI studies.Frontiers in neuroscience · 2026Pooled it
- Distinct and shared neurobiological patterns in PTSD and CPTSD: evidence from resting-state fMRI.BMC psychiatry · 2026Article
- Trauma Timing and Its Impact on Brain Activation During Flexible Emotion Regulation in PTSD: Insights From Functional MRI.Human brain mapping · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Patients with Post-Traumatic Stress Disorder (PTSD) exhibit deficits in flexible emotion regulation and display abnormal brain activation patterns. Previous research has not examined how the age at which trauma occurs influences associated behavioral and neural abnormalities. In this study, 76 adult participants (60.5% women) diagnosed with PTSD were categorized into three age-matched groups based on the age at trauma onset: childhood, adolescence, and adulthood. Forty-five healthy adults served as a control group. All participants engaged in the Shifted Attention Emotion Appraisal Task (SEAT) while undergoing functional magnetic resonance imaging (fMRI). Our findings reveal that both the childhood and adulthood trauma groups showed significantly greater activation in the left thalamus, left frontal gyrus, and Brodmann Area 48 compared to the adolescent trauma group. Additionally, the childhood trauma group exhibited higher activation in the left inferior frontal gyrus than the adolescent group and greater activation in the left pregenual anterior cingulate cortex compared to the adulthood trauma group. These results highlight the critical role of trauma timing in understanding the behavioral and neural dimensions of PTSD, offering new insights for clinical intervention and treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.