ArticleAngewandte Chemie (International ed. in English)2025
Supramolecular Interactions Modulate RNA:DNA Folding Observed via Nanopore Sensing.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Modular RNA:DNA Nanostructures Enable Nanopore Profiling of rRNA Processing and rRNA Variants.ACS nano · 2026Article
- Comparative Benchmarking of Glass and Silicon Nitride Nanopores for Single-Molecule Detection.ACS nano · 2026Article
- Supramolecular Interactions Modulate RNA:DNA Folding Observed via Nanopore Sensing.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
DNA and RNA nanotechnology enables the precise assembly of molecular architectures, with applications in bioengineering, supramolecular chemistry, and sensing. The material properties of these biopolymers can be adjusted covalently or, more simply, through non-covalent interactions with small molecules. Herein, we demonstrate the use of urea, an abundant and inexpensive small molecule, to modulate the stiffness of RNA:DNA hybrid nanostructures. Our results suggest that supramolecular interactions between urea and the A-form-like helix rigidify the hybrid polymers, as evidenced by both solid-state nanopore measurements and atomic force microscopy. Nanopore sensing reveals that preparing topologically-barcoded RNA:DNA hybrids in urea results in a 50% reduction in folded translocations. This decrease in folded events improves the proportion of useable data points, paving the way for the robust detection of low-abundance RNA analytes at the single-molecule level.
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Registered trials
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