ArticleContact dermatitis2026
Octylisothiazolinone-A New Sensitizer in Over-Ear Headphones.
Article in Contact dermatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Octylisothiazolinone-A New Sensitizer in Over-Ear Headphones.Contact dermatitis · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllergic contact dermatitis (ACD) caused by isothiazolinones is a growing concern, particularly in consumer products. Octylisothiazolinone (OIT) is a potent sensitiser and commonly used as a preservative in rubbers, plastics and coatings, including those found in headphones. Despite increasing regulations on isothiazolinones in cosmetics, their presence in wearable devices remains under-recognised.
aimsThis investigation aims to identify OIT as a possible sensitiser in patients with presumed ACD due to over-ear headphones.
methodsTwo patients with presumed ACD due to over-ear headphones were patch tested at the Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö. Patch testing included Swedish baseline series, isothiazolinone compounds, and materials from headphones. To identify potential allergens, chemical analysis of components from headphones was conducted using high-performance liquid chromatography (HPLC).
resultsPatch testing demonstrated strong positive reactions to OIT in both cases, with additional reactions to acetone extracts of artificial leather and blue plastic foam. OIT remained positive at dilutions as low as 0.00003%. Case 1 also showed positive reactions to MI/MCI. Chemical analysis confirmed OIT in both artificial leather (2.2 mg/g) and plastic foam (0.3 mg/g).
conclusionsThese findings contribute to the understanding of ACD by identifying OIT as a potential allergen in over-ear headphones. It calls for further research into the prevalence of OIT in consumer electronics and its role in sensitisation.
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