Evidence map›Paper›PMID 40944438›Full record

ArticleProtein science : a publication of the Protein Society2025

Hydrophobic residues in the D-domain of a plasminogen-binding M-protein modulate α-helicity, oligomerization, and surface anchoring in Streptococcus pyogenes.

Olawole Ayinuola, Yetunde A Ayinuola, Zhong Liang, Francis J Castellino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olawole AyinuolaW.M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Yetunde A AyinuolaW.M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Zhong LiangW.M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Francis J CastellinoW.M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0003-0317-9539

Funding

STRUCTURE-FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR01HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 1985 to 2021
$7.9M
Plasminogen and Plasmin: Structure and FunctionR56HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 2022 to 2022
$743k
NHLBI NIH HHS R01 HL013423NHLBI NIH HHS R56 HL013423NIH HHS HL-13423
6 · The paper itself

Abstract

Human plasminogen (hPg) binding M-protein (PAM) is a major virulence determinant of Group A Streptococcus (GAS). PAM contains irregularly spaced heptad repeats, particularly within its C- and D-domains. Our recent cryo-EM structure of PAM from GAS strain AP53 (PAM

Indexed as

Bacterial Outer Membrane ProteinsBacterial ProteinsCarrier ProteinsPlasminogenStreptococcus pyogenesAntigens, BacterialHumansHydrophobic and Hydrophilic InteractionsModels, MolecularProtein Conformation, alpha-HelicalProtein DomainsProtein MultimerizationAntigens, BacterialBacterial Outer Membrane ProteinsBacterial ProteinsCarrier ProteinsPlasminogenstreptococcal M proteinbacterial M‐proteinbacterial surfacehPg activationM‐protein D‐domainprotein engineeringsupersecondary structure

Identifiers

PMID40944438
PMCPMC12432430

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.