Evidence map›Paper›PMID 40944417›Full record

ArticleCancer medicine2025

NIBAN2 Stimulates Glioma Growth by Regulating the JAK2/STAT3/c-Myc Pathway.

Zhi-Ming Chen, Lei Mou, Yi-Heng Pan, Chi Feng, Jun Liu, Jing-Jing Zhang, Chang-Xiang Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhi-Ming ChenDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Lei MouDepartment of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, People's Republic of China.
Yi-Heng PanDepartment of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, People's Republic of China.
Chi FengDepartment of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, People's Republic of China.
Jun LiuDepartment of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, People's Republic of China.ORCID https://orcid.org/0000-0002-6659-0109
Jing-Jing ZhangDepartment of Obstetrics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, People's Republic of China.
Chang-Xiang YanDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0003-8506-8628

Funding

Key Research and Development Program, Ministry of Science and Technology of China 2023YFC2510000Research Grant of the Clinical Medical Research Center for Central Nervous System Repair and Functional Reconstruction of Hubei Province
6 · The paper itself

Abstract

backgroundNiban-like protein 2 (NIBAN2) has recently been linked to various neurological diseases; however, its exact role in glioma development remains unclear.

methodsQuantitative reverse transcription-polymerase chain reaction, western blotting, and immunohistochemistry were used to evaluate NIBAN2 expression in glioma tissues. In addition, we examined the effects of NIBAN2 on glioma progression in various functional trials. Animal models were used to clarify the role of NIBAN2, especially its impact on the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway.

resultsThe research outcomes revealed that NIBAN2 was highly upregulated in gliomas and its levels were strongly correlated with tumor grade and clinical outcomes. Functional assays showed that NIBAN2 enhanced glioma cell aggressiveness by activating JAK2/STAT3 signaling and promoted tumor growth by preventing apoptosis and accelerating the cell cycle.

conclusionThe findings of this study show that NIBAN2 plays a key role in glioma aggression and poor prognosis, suggesting that it is a potential therapeutic target.

Indexed as

Brain NeoplasmsGliomaJanus Kinase 2Proto-Oncogene Proteins c-mycSTAT3 Transcription FactorAnimalsApoptosisCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudeMiddle AgedJAK2 protein, humanJanus Kinase 2MYC protein, humanProto-Oncogene Proteins c-mycSTAT3 protein, humanSTAT3 Transcription FactorgliomasJAK2/STAT3/MYCNIBAN2proliferation

Identifiers

PMID40944417
PMCPMC12432436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.