Evidence map›Paper›PMID 40944410›Full record

ArticleActa biochimica et biophysica Sinica2025

Exosomal miR-146a-3p modulates neural stem cell fate through UCHL1 downregulation in spinal cord injury: implications for neuroregeneration.

Ying Gao, Ziwen Shi, Suhe Zhang, Zhiqiang Wu, Tao Zhou, Pinghui Zhou, Weiwei Chu, Xuyi Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying GaoDepartment of Anesthesiology, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Ziwen ShiDepartment of Orthopaedics, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Suhe ZhangDepartment of Orthopaedics, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Zhiqiang WuDepartment of Orthopaedics, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Tao ZhouAnhui Province Key Laboratory of Tissue Transplantation, Bengbu Medical University, Bengbu 233000, China.
Pinghui ZhouDepartment of Orthopaedics, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Weiwei ChuDepartment of Plastic Surgery, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Xuyi WangDepartment of Orthopaedics, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) poses a substantial challenge within the field of regenerative medicine, primarily because of its high incidence of disability and the paucity of effective therapeutic interventions. This study explores the involvement of cerebrospinal fluid (CSF) exosomes in the differentiation of neural stem cells (NSCs) following SCI, with a particular emphasis on the miR-146a-3p/UCHL1 signaling axis. Using an SCI animal model, we analyze the molecular composition of CSF and its influence on NSC fate through bioinformatics approaches, dual-luciferase reporter assays, and

Indexed as

cerebrospinal fluidexosomemiR-146a-3pneural stem cellspinal cord injuryUCHL1

Identifiers

PMID40944410
PMCPMC13107014

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.