SynthesisAnnals of medicine2025
Efficacy and safety of methylene blue for postoperative pain of haemorrhoids: a systematic review and meta-analysis.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- The effect of methylene blue infiltrating injection on anal pain after Milligan-Morgan surgery: A randomized controlled clinical study.Medicine · 2026Trial
- Comparison of compound methylene blue (methylene blue + ropivacaine) and bupivacaine liposome for pain control after mixed hemorrhoid surgery: A comprehensive analysis based on clinical studies.The Journal of international medical research · 2026Observational
- Regarding: "Efficacy and safety of methylene blue for postoperative pain of haemorrhoids: a systematic review and meta-analysis".Annals of medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPain is a common complication after haemorrhoid surgery. In addition to anaesthetic methods, surgical techniques and postoperative interventions, surgeons also use intraoperative adjuncts to alleviate postoperative pain. This study aims to evaluate the effectiveness and safety of methylene blue in reducing postoperative pain in haemorrhoid patients.
methodsA search was conducted in PubMed, Embase, Cochrane Library and Web of Science for randomized controlled trials (RCTs) up until 9 December 2024, involving methylene blue use for pain relief after haemorrhoid surgery. Two reviewers independently assessed the study eligibility, extracted data and evaluated the risk of bias. Data analysis was performed using Stata 18 software. The primary outcome was the visual analogue scale (VAS) pain scores at different time points within 14 days postoperatively. Secondary outcomes included the number of patients requiring analgesics and the occurrence of complications.
results358 articles were retrieved and six studies involving 598 patients were included after screening. Compared with the control group, the use of methylene blue reduced pain within 12 h postoperatively(WMD -1.582, 95% CI -2.834 to -0.330,
conclusionsThis study shows that methylene blue can reduce postoperative pain, decrease analgesic use and does not increase complications after haemorrhoid surgery.
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