Evidence map›Paper›PMID 40944280›Full record

ArticleNutrients2025

Sapropterin Dihydrochloride Responsiveness in Phenylketonuria: A Case Series Exploring Gaps in Comprehensive Patient Monitoring.

Manuela Lo Bianco, Roberta Leonardi, Alessia Migliore, Evelina Moliteo, Monica Sciacca, Sergio Rinella, Maria Grazia Pappalardo, Luisa La Spina, Marianna Messina, Riccardo Iacobacci and 3 more

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Manuela Lo BiancoUnit of Pediatric Clinic, A.O.U. Policlinico "G. Rodolico-San Marco", P.O. "G. Rodolico"-University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5413-419X
Roberta LeonardiPostgraduate Residency Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5566-4387
Alessia MigliorePostgraduate Residency Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Evelina MoliteoPostgraduate Residency Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-7588-4926
Monica SciaccaPostgraduate Residency Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Sergio RinellaDepartment of Educational Sciences, University of Catania, 95131 Catania, Italy.ORCID 0000-0002-9368-7088
Maria Grazia PappalardoUnit of Expanded Neonatal Screening and Inherited Metabolic Diseases, Pediatric Clinic, Department of Medical Sciences, University of Catania, 95123 Catania, Italy.
Luisa La SpinaUnit of Expanded Neonatal Screening and Inherited Metabolic Diseases, Pediatric Clinic, Department of Medical Sciences, University of Catania, 95123 Catania, Italy.
Marianna MessinaUnit of Expanded Neonatal Screening and Inherited Metabolic Diseases, Pediatric Clinic, Department of Medical Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8652-4248
Riccardo IacobacciUnit of Expanded Neonatal Screening and Inherited Metabolic Diseases, Pediatric Clinic, Department of Medical Sciences, University of Catania, 95123 Catania, Italy.
Martino RuggieriUnit of Pediatric Clinic, A.O.U. Policlinico "G. Rodolico-San Marco", P.O. "G. Rodolico"-University of Catania, 95123 Catania, Italy.ORCID 0000-0002-2658-4249
Concetta MeliUnit of Expanded Neonatal Screening and Inherited Metabolic Diseases, Pediatric Clinic, Department of Medical Sciences, University of Catania, 95123 Catania, Italy.
Agata PolizziUnit of Pediatric Clinic, A.O.U. Policlinico "G. Rodolico-San Marco", P.O. "G. Rodolico"-University of Catania, 95123 Catania, Italy.ORCID 0000-0002-4865-0200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiopterinsPhenylketonuriasAdolescentAdultChildChild, PreschoolFemaleHumansMalePhenylalaninePhenylalanine HydroxylaseRetrospective StudiesTreatment OutcomeYoung AdultBiopterinsPhenylalaninePhenylalanine HydroxylasesapropterinBH4 loading testinternational best practicephenylalanine hydroxylase (PAH)phenylketonuria (PKU)sapropterin dihydrochloride

Identifiers

PMID40944280
PMCPMC12429939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.