Observational studyNutrients2025
Influence of Gestational Age on the Level of Functional Peptides (Peptidome) in Breast Milk.
Observational study in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND/
objectivesHuman milk provides essential nutrients and immune factors with beneficial impact on term, but especially preterm infants' development. Therefore, this study focuses on the quantification of differences in the peptidome composition of breast milk from mothers of preterm and term infants, keeping in mind that this could reflect different biological needs of these infants or indicate nutritional gaps for healthy development.
methodsIn a prospective observational study, breast milk samples were collected from 10 mothers of preterm infants (29-36 weeks gestational age,) and 13 mothers of term infants (37-41 weeks) at day 4 to 6 postnatally. A non-targeted tandem mass spectrometry approach was employed to analyze the milk peptidome.
resultsIn total, 4570 peptides were quantified. Adjusting the results for maternal age, weight, and height revealed a significant difference for 130 peptides derived from 19 different proteins between preterm and term milk. Proteins comprised high abundant proteins (e.g., α
conclusionsThe current study provides a comprehensive overview on the differences in the milk peptidome at different gestational ages independent from common maternal phenotypes and improved the database for future peptide functionality studies.
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