Evidence map›Paper›PMID 40943662›Full record

ReviewInternational journal of molecular sciences2025

Richter Transformation in Chronic Lymphocytic Leukemia: Current Treatment Challenges and Evolving Therapies.

Zi-Chi Lin, Ming-Jen Chan, Tang-Her Jaing, Tung-Liang Lin, Yu-Shin Hung, Yi-Jiun Su

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zi-Chi LinDivision of Hematology-Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.
Ming-Jen ChanDepartment of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.ORCID 0000-0003-1482-8557
Tang-Her JaingCollege of Medicine, Chang Gung University, Taoyuan 333423, Taiwan.ORCID 0000-0002-5407-1555
Tung-Liang LinDivision of Hematology-Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.ORCID 0000-0002-9532-749X
Yu-Shin HungDivision of Hematology-Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.
Yi-Jiun SuDivision of Hematology-Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.ORCID 0000-0002-8372-1166

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Richter transformation (RT) affects 2-10% of chronic lymphocytic leukemia (CLL) patients, evolving into an aggressive lymphoma-most often diffuse large B-cell lymphoma-with poor prognosis, especially when clonally related to CLL. Key risk factors include unmutated IGHV,

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellLymphoma, Large B-Cell, DiffuseAntineoplastic Combined Chemotherapy ProtocolsHematopoietic Stem Cell TransplantationHumansImmunotherapyallogeneic hematopoietic stem cell transplantationBCL-2 inhibitorsbispecific antibodiesBTK inhibitorsCAR T-cell therapychemoimmunotherapychronic lymphocytic leukemiaRichter transformation

Identifiers

PMID40943662
PMCPMC12429326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.