Evidence map›Paper›PMID 40943659›Full record

ArticleInternational journal of molecular sciences2025

Regulatory Mechanisms of SPARC Overexpression in Melanoma Progression.

Antònia Vinyals, Josep R Ferreres, Rafael Campos-Martín, Olga J C Torres, Jessica Mainez, Joan A Puig-Butillé, Joaquim Marcoval, Susana Puig, Isabel Fabregat, Àngels Fabra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antònia VinyalsTGF-β and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.ORCID 0000-0003-3925-0050
Josep R FerreresTGF-β and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.ORCID 0000-0002-2679-3067
Rafael Campos-MartínDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, 50923 Köln, Germany.
Olga J C TorresJosep Carreras Leukaemia Research Institute (IJC), Badalona, 08916 Barcelona, Spain.ORCID 0000-0002-1219-8865
Jessica MainezInstitute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain.ORCID 0000-0002-7345-6290
Joan A Puig-ButilléFundació Clínic de Recerca Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic Barcelona, Universitat de Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-4345-9631
Joaquim MarcovalDermatology Service, Hospital Universitari de Bellvitge, 08907 Barcelona, Spain.
Susana PuigFundació Clínic de Recerca Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic Barcelona, Universitat de Barcelona, 08036 Barcelona, Spain.
Isabel FabregatTGF-β and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.ORCID 0000-0003-0136-8440
Àngels FabraTGF-β and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.

Funding

"Fundació La Marató de TV3" (201331-30 to S.P. and 201331-32 to A.F.), the "Asociación Española Contra el Cáncer" (GCB15152978SOEN), AGAUR (2017SGR0188 and 2021SGR00029) ;Instituto de Salud Carlos III (ISCIII) through projects PI18/00419, PI22/01457 (Co-f La Marató de TV3" (201331-30 to S.P. and 201331-32 to A.F.), ; "Asociación Española Contra el Cáncer" (GCB15152978SOEN); AGAUR (2017SGR0188 and 2021SGR00029);Instituto de Salud Carlos III (ISCIII) through projects PI18/00419, PI22/01457;
6 · The paper itself

Abstract

The expression of the Secreted Protein, Acidic and Rich in Cysteine (

Indexed as

Gene Expression Regulation, NeoplasticMelanomaOsteonectinCell Line, TumorDisease ProgressionEpithelial-Mesenchymal TransitionHomeodomain ProteinsHumansMicroRNAsPromoter Regions, GeneticSp1 Transcription FactorTranscription Factor 7-Like 2 ProteinHomeodomain ProteinsMicroRNAsOsteonectinPRRX1 protein, humanSp1 Transcription FactorSPARC protein, humanTCF7L2 protein, humanTranscription Factor 7-Like 2 Proteincutaneous melanomaEMTmiR-29PRRX1Sp1SPARCTCF7L2

Identifiers

PMID40943659
PMCPMC12429502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.