Evidence map›Paper›PMID 40943558›Full record

ArticleInternational journal of molecular sciences2025

Combined Photodynamic Therapy and Chemotherapy Using Local Intra-Arterial Intratumoral Administration of Chlorin e6 and Cisplatin: First Clinical Observations.

Kanamat Efendiev, Artem Shiryaev, Aidai Rakhmanova, Tatiana Pisareva, Alena Mamedova, Svetlana Samoylova, Igor Reshetov, Alexey Skobeltsin, Anna Krivetskaya, Anastasia Ryabova and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kanamat EfendievProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-5864-1172
Artem ShiryaevDepartment of Oncology, Radiotherapy and Reconstructive Surgery, Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.ORCID 0000-0001-9421-420X
Aidai RakhmanovaDepartment of Oncology, Radiotherapy and Reconstructive Surgery, Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.ORCID 0009-0000-5323-9056
Tatiana PisarevaDepartment of Oncology, Radiotherapy and Reconstructive Surgery, Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Alena MamedovaDepartment of Oncology, Radiotherapy and Reconstructive Surgery, Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Svetlana SamoylovaDepartment of Oncology, Radiotherapy and Reconstructive Surgery, Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Igor ReshetovDepartment of Oncology, Radiotherapy and Reconstructive Surgery, Levshin Institute of Cluster Oncology, Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Alexey SkobeltsinProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.
Anna KrivetskayaProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0003-2221-0407
Anastasia RyabovaProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0003-3488-1128
Vladimir MakarovProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0001-9622-1550
Victor LoschenovProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-0507-2367

Funding

Russian Science Foundation 25-12-00436
6 · The paper itself

Abstract

Despite advances in cancer treatment, head and neck squamous cell carcinoma (HNSCC) remains a serious clinical problem due to tumor aggressiveness, tumor resistance to therapy, and treatment toxicity. The combination of photodynamic therapy (PDT) with chemotherapy is a promising approach to improve efficacy while reducing side effects. For the first time, the possibility and antitumor effect of the combined use of PDT and chemotherapy with intra-arterial administration of chlorin e6 (Ce6) and cisplatin in patients with HNSCC were assessed. Two patients with locally advanced HNSCC received intra-arterial administration of Ce6 (at a dose of 0.5 mg/kg) and cisplatin (at a dose of 50 mg/m

Indexed as

Antineoplastic AgentsCisplatinHead and Neck NeoplasmsPhotochemotherapyPhotosensitizing AgentsPorphyrinsSquamous Cell Carcinoma of Head and NeckChlorophyllidesCombined Modality TherapyHumansTreatment OutcomeAntineoplastic AgentsChlorophyllidesCisplatinPhotosensitizing AgentsphytochlorinPorphyrinschemotherapeutic agentchemotherapychlorin e6cisplatinextracellular matrixfluorescence diagnosticshead and neck squamous cell carcinomaintra-arterial administrationphotodynamic therapyphotosensitizertargeted therapy

Identifiers

PMID40943558
PMCPMC12429688

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.