Evidence map›Paper›PMID 40943526›Full record

ArticleInternational journal of molecular sciences2025

Nebulized Bacterioruberin/Astaxanthin-Loaded Nanovesicles: Antitumoral Activity and Beyond.

Victoria Rebeca Dana González Epelboim, Diego G Lamas, Cristián Huck-Iriart, Ezequiel Nicolas Caputo, Maria Julia Altube, Horacio Emanuel Jerez, Yamila Roxana Simioni, Kajal Ghosal, Maria Jose Morilla, Leticia Herminia Higa and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bacterioruberin fromInternational journal of molecular sciences · 2026
    Article
  2. Recent Advances in Understanding Bio-Compounds from Haloarchaea.Journal of microbiology and biotechnology · 2026
    Review
  3. Bacterioruberin (CNutrients · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Victoria Rebeca Dana González EpelboimNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, Buenos Aires, Argentina.ORCID 0009-0002-6397-1130
Diego G LamasLaboratorio de Cristalografía Aplicada (LCA), Instituto de Tecnologías Emergentes y Ciencias Aplicadas (ITECA), Escuela de Ciencia y Tecnología (ECyT), UNSAM-CONICET, Campus Miguelete, San Martín 1650, Buenos Aires, Argentina.ORCID 0000-0002-9099-586X
Cristián Huck-IriartLaboratorio de Cristalografía Aplicada (LCA), Instituto de Tecnologías Emergentes y Ciencias Aplicadas (ITECA), Escuela de Ciencia y Tecnología (ECyT), UNSAM-CONICET, Campus Miguelete, San Martín 1650, Buenos Aires, Argentina.ORCID 0000-0001-5734-2499
Ezequiel Nicolas CaputoNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, Buenos Aires, Argentina.ORCID 0000-0002-6236-4083
Maria Julia AltubeNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, Buenos Aires, Argentina.ORCID 0000-0002-5902-327X
Horacio Emanuel JerezNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, Buenos Aires, Argentina.ORCID 0000-0003-3335-0288
Yamila Roxana SimioniNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, Buenos Aires, Argentina.
Kajal GhosalDepartment of Pharmaceutical Technology, Jadavpur University, 188, Raja Subodh Chandra Mallick Rd., Jadavpur, Kolkata 700032, West Bengal, India.ORCID 0000-0001-6392-2182
Maria Jose MorillaNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, Buenos Aires, Argentina.
Leticia Herminia HigaNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, Buenos Aires, Argentina.ORCID 0000-0002-6025-8949
Eder Lilia RomeroNanomedicine Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, Bernal 1876, Buenos Aires, Argentina.ORCID 0000-0003-3020-1746

Funding

CONICET PIP 2021-2023 N◦ 11220200102694COSecretaria de Investigaciones, Universidad Nacional de Quilmes Programa de Nanomedicinas-2
6 · The paper itself

Abstract

The membranes of halophilic archaea are a source of novel biomaterials, mainly of isoprenoid nature, with therapeutic properties practically unraveled. Here, we explored the antitumoral activity of neutral archaeolipids (NAs, such as bacterioruberin, astaxanthin, and dihydrosqualene) present in the total archaeolipids (TAs) (a fraction from the first step of lipid extraction by the modified Blight and Dyer technique) extracted from halophilic archaea Halorubrum tebenquichense, and formulated as TA-nanoarchaeosomes (TA: polar archaeolipids (PAs): Tween 80, 5:5:4

Indexed as

Antineoplastic AgentsAntioxidantsCarotenoidsNanoparticlesXanthophyllsCell LineCell SurvivalHumansLipidsLysosomesMacrophagesMembrane Potential, MitochondrialMitochondrial MembranesNebulizers and VaporizersReactive Oxygen SpeciesSpectroscopy, Fourier Transform InfraredAntineoplastic AgentsAntioxidantsastaxanthinebacterioruberinCarotenoidsLipidsReactive Oxygen SpeciesXanthophyllsinhalationlungsxanthophylls

Identifiers

PMID40943526
PMCPMC12429319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.