Evidence map›Paper›PMID 40943492›Full record

ArticleInternational journal of molecular sciences2025

Molecular Imbalances Between Striosome and Matrix Compartments Characterize the Pathogenesis and Pathophysiology of Huntington's Disease Model Mouse.

Ryoma Morigaki, Tomoko Yoshida, Joji Fujikawa, Jill R Crittenden, Ann M Graybiel

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Noninvasive Mapping of Striosome-Matrix Imbalance in Early Psychosis.Biological psychiatry global open science · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryoma MorigakiMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-4919-6441
Tomoko YoshidaMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-3961-0095
Joji FujikawaDepartment of Advanced Brain Research, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.ORCID 0000-0001-5082-3759
Jill R CrittendenMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ann M GraybielMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-4326-7720

Funding

Functional and anatomical characterization of the striosomal systemR01MH060379 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Ann M Graybiel · 2000 to 2026
$8.7M
Beauty Life Corporation N/ACHDI Foundation A-5552Japan Society for the Promotion of Science 16KK0182Japan Society for the Promotion of Science 17K10899Kristin R. Pressman and Jessica J. Pourian '13 Fund N/ANIMH NIH HHS R01 MH060379Saks-Kavanaugh Foundation N/A
6 · The paper itself

Abstract

The pathogenesis and pathophysiology of Huntington's disease (HD) are still incompletely understood, despite the remarkable advances in identifying the molecular effects of the

Indexed as

Corpus StriatumHuntington DiseaseAnimalsCyclic AMPDisease Models, AnimalGene Knock-In TechniquesGTP-Binding Protein alpha SubunitsHuntingtin ProteinMiceMice, TransgenicPhosphoric Diester HydrolasesReceptors, Dopamine D1Receptors, Dopamine D2Cyclic AMPGTP-Binding Protein alpha SubunitsHuntingtin ProteinPde10a protein, mousePhosphoric Diester HydrolasesReceptors, Dopamine D1Receptors, Dopamine D2choreadopaminedystoniaHuntington’s diseasemovement disordersneostriatumolfactory type G-protein alpha subunitPDE10Astriosome

Identifiers

PMID40943492
PMCPMC12429560

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.