Evidence map›Paper›PMID 40943448›Full record

ArticleInternational journal of molecular sciences2025

Scaffold-Hopping Design and Synthesis of Thieno[3,2-

Zukela Ruzi, Anvarjon Buronov, Lifei Nie, Azizbek Nasrullaev, Zarifa Murtazaeva, Rustamkhon Kuryazov, Jiangyu Zhao, Thomas Efferth, Haji Akber Aisa, Khurshed Bozorov

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Thieno[3,2-International journal of molecular sciences · 2026
    Review
  2. Discovery of thieno[3,2-RSC advances · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zukela RuziState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.
Anvarjon BuronovDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.ORCID 0000-0003-1887-6804
Lifei NieState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.
Azizbek NasrullaevDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.
Zarifa MurtazaevaDepartment of Organic Synthesis and Bioorganic Chemistry, Institute of Biochemistry, Samarkand State University, University Blvd. 15, Samarkand 140104, Uzbekistan.
Rustamkhon KuryazovDepartment of Chemistry, Urgench State University, Kh. Olimjon st. 14, Urgench 220100, Uzbekistan.ORCID 0000-0001-9665-9982
Jiangyu ZhaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.
Thomas EfferthDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.ORCID 0000-0002-2637-1681
Haji Akber AisaState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.ORCID 0000-0003-4652-6879
Khurshed BozorovState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Rd 40-1, Urumqi 830011, China.ORCID 0000-0001-7449-0936

Funding

Chinese Academy of Sciences President's International Fellowship Initiative 2024VBA0021Organization of the Laboratory for the Creation of anticancer drugs ALM-202310062530
6 · The paper itself

Abstract

Two series of tricyclic thieno[3,2-

Indexed as

Antineoplastic AgentsApoptosisCyclin-Dependent KinasesProtein Kinase InhibitorsPyrimidinesCell CycleCell Line, TumorCell MovementCell ProliferationDrug DesignHeLa CellsHT29 CellsHumansMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsCyclin-Dependent KinasesProtein Kinase InhibitorsPyrimidinesthieno(2,3-d)pyrimidineanticancer activityapoptosis inductionCDK1cell cycle arrestcyclin-dependent kinases (CDKs)in silico studymolecular dockingscaffold-hopping synthesisthieno[3,2-d]pyrimidines

Identifiers

PMID40943448
PMCPMC12429047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.