Evidence map›Paper›PMID 40943395›Full record

ArticleInternational journal of molecular sciences2025

C14DM Ablation Leads to Reduced Tolerance to Plasma Membrane Stress and Increased Drug Sensitivity in

Samrat Moitra, Sumit Mukherjee, Veronica L Hernandez, Kai Zhang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samrat MoitraDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-2857-9590
Sumit MukherjeeDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0003-2534-6270
Veronica L HernandezDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-5200-7381
Kai ZhangDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-6616-1806

Funding

Identification of CYP5122A1 inhibitors as chemical probes for Leishmania biologyR01AI139198 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI WANG, ZHUO MICHAEL · 2019 to 2022
$2.1M
Phospholipid metabolism in LeishmaniaR15AI156746 · NIAID · TEXAS TECH UNIVERSITY · PI ZHANG, KAI · 2021 to 2024
$959k
NIAID NIH HHS R01 AI139198NIAID NIH HHS R15 AI156746NIH Common Fund R01AI139198NIH HHS 1R15AI156746-01
6 · The paper itself

Abstract

Sterol biosynthesis is crucial for the function of biological membranes and an important target for anti-protozoan/anti-fungal drugs. In the trypanosomatid parasite

Indexed as

Antiprotozoal AgentsCell MembraneDrug ResistanceLeishmania majorProtozoan ProteinsSterol 14-DemethylaseAnimalsAutophagosomesItraconazoleMiceOsmotic PressureAntiprotozoal AgentsItraconazoleProtozoan ProteinsSterol 14-DemethylaseLeishmaniasterolsynergy

Identifiers

PMID40943395
PMCPMC12429082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.