Evidence map›Paper›PMID 40943348›Full record

ArticleInternational journal of molecular sciences2025

Quantitative Structure-Activity Relationship Study of Cathepsin L Inhibitors as SARS-CoV-2 Therapeutics Using Enhanced SVR with Multiple Kernel Function and PSO.

Shaokang Li, Zheng Li, Peijian Zhang, Aili Qu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shaokang LiCollege of Computer Science and Technology, Qingdao University, Qingdao 266071, China.
Zheng LiCollege of Computer Science and Technology, Qingdao University, Qingdao 266071, China.
Peijian ZhangCollege of Computer Science and Technology, Qingdao University, Qingdao 266071, China.
Aili QuSchool of Economics, Qingdao University, Qingdao 266071, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cathepsin L (CatL) is a critical protease involved in cleaving the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), facilitating viral entry into host cells. Inhibition of CatL is essential for preventing SARS-CoV-2 cell entry, making it a potential therapeutic target for drug development. Six QSAR models were established to predict the inhibitory activity (expressed as IC

Indexed as

Antiviral AgentsCathepsin LAlgorithmsCOVID-19COVID-19 Drug TreatmentHumansMolecular Docking SimulationQuantitative Structure-Activity RelationshipSARS-CoV-2Support Vector MachineAntiviral AgentsCathepsin LCTSL protein, humanCathepsin L inhibitormolecular dockingparticle swarm optimizationSARS-CoV-2support vector regression

Identifiers

PMID40943348
PMCPMC12428938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.