ArticleInternational journal of molecular sciences2025
Structural-Scaling Transitions and Criticality Cascade in DNA with Open States.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article investigates the mechanism of self-organized DNA criticality with open states, which plays a key role in the regulation of gene expression and consequently in cell fate determination. Based on a mechanobiological model developed using methods of statistical physics and thermodynamics, we demonstrate that the collective behavior of DNA open-state ensembles governs transitions between bistable, metastable, and critical genomic states. These states correspond to different gene expression scenarios involved in cell fate determination. Through simulation results, we introduce the concept of a criticality cascade, linking the dynamics of the DNA molecule structural parameter χ with global changes in cellular processes. The findings align with experimental data and offer new perspectives for studying genome regulation mechanisms, including pathological conditions such as cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.