Evidence map›Paper›PMID 40943344›Full record

Observational studyInternational journal of molecular sciences2025

Early Insights from Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Patients: An Observational Study on Polygenic Risk and Liver Biomarkers.

Pietro Torre, Benedetta Maria Motta, Tommaso Sarcina, Mariano Festa, Mario Masarone, Marcello Persico

Abstract readObservational Study
In one paragraph

Observational study in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pietro TorreDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081 Baronissi, Italy.ORCID 0000-0001-8245-5305
Benedetta Maria MottaDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081 Baronissi, Italy.ORCID 0000-0002-6681-2170
Tommaso SarcinaDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081 Baronissi, Italy.
Mariano FestaDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081 Baronissi, Italy.ORCID 0009-0006-4551-2589
Mario MasaroneDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081 Baronissi, Italy.ORCID 0000-0003-0550-8201
Marcello PersicoDepartment of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Via S. Allende, 84081 Baronissi, Italy.ORCID 0000-0002-1399-6498

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern influenced by both genetic and metabolic factors. Polygenic risk scores (PRSs), which combine the effects of known single-nucleotide polymorphisms (SNPs), may improve early risk stratification. We conducted an observational study on 298 MASLD patients: 148 from a Hepatology Unit and 150 from a Bariatric Surgery Unit. Genotyping was performed for the

Indexed as

Fatty LiverMultifactorial InheritanceAcyltransferasesAdaptor Proteins, Signal TransducingAdultBiomarkersFemaleGenetic Predisposition to DiseaseGenotypeHumansLipaseLiverLiver CirrhosisMaleMembrane ProteinsMiddle AgedAcyltransferasesAdaptor Proteins, Signal TransducingBiomarkersGCKR protein, humanLipaseMBOAT7 protein, humanMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanTM6SF2 protein, humanliver fibrosismetabolic dysfunction-associated steatotic liver diseasepolygenic risk score

Identifiers

PMID40943344
PMCPMC12428583

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.