Evidence map›Paper›PMID 40943294›Full record

ArticleInternational journal of molecular sciences2025

Examining the Roles of Genomic Context and Endogenous Regulatory Elements on IS

Sofia Smith, Zhongge Zhang, Allyson Ho, Tusha Karnani, Jack Ord, Milton H Saier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sofia SmithDepartment of Molecular Biology, School of Biological Sciences, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093-0116, USA.ORCID 0009-0007-1273-2005
Zhongge ZhangDepartment of Molecular Biology, School of Biological Sciences, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093-0116, USA.
Allyson HoDepartment of Molecular Biology, School of Biological Sciences, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093-0116, USA.
Tusha KarnaniDepartment of Molecular Biology, School of Biological Sciences, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093-0116, USA.
Jack OrdDepartment of Molecular Biology, School of Biological Sciences, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093-0116, USA.
Milton H SaierDepartment of Molecular Biology, School of Biological Sciences, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093-0116, USA.

Funding

The Transporter Classification Database (TCDB)R01GM077402 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAIER, MILTON H. · 2006 to 2021
$4.7M
NIGMS NIH HHS R01 GM077402NIH HHS 1R01GM077402-04
6 · The paper itself

Abstract

Insertion sequence (IS) elements are key drivers of bacterial genome plasticity, yet the overall regulation of their transposition remains poorly understood. This is especially true for the multiple-layer regulation at the donor site, which has been largely overlooked. Using multiple mutation assays, genetic manipulations and reporter genes, this study focuses on characterizing how endogenous DNA sequences, transcriptional and translational factors, and genomic context regulate IS

Indexed as

DNA Transposable ElementsEscherichia coliGenome, BacterialRegulatory Sequences, Nucleic AcidEscherichia coli ProteinsGene Expression Regulation, BacterialTransposasesDNA Transposable ElementsEscherichia coli ProteinsTransposasesgenomic contextInsAinsertion sequenceintrinsic sequenceIS1replicative vs. non-replicative mechanismribosomal frameshifttransposable element

Identifiers

PMID40943294
PMCPMC12428005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.