Evidence map›Paper›PMID 40943286›Full record

ArticleInternational journal of molecular sciences2025

Association of Circulating miRNAs from the C19MC Cluster and IGF System with Macrosomia in Women with Gestational Diabetes Mellitus.

Magalhi Guadalupe Robledo-Clemente, Juan Carlos Silva Godínez, Mary Flor Díaz-Velázquez, Edgar Mendoza Reyes, José Damián Gómez Archilla, Lucia Daniela García Montes, Mauricio Ramiro Cortez Chávez, María Isabel Peña-Cano, Renata Saucedo

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Magalhi Guadalupe Robledo-ClementeUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 3 "Dr. Víctor Manuel Espinosa de los Reyes Sánchez", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México City 02990, Mexico.ORCID 0009-0000-8661-2611
Juan Carlos Silva GodínezPPCR Program, ECPE Department, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Mary Flor Díaz-VelázquezUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 3 "Dr. Víctor Manuel Espinosa de los Reyes Sánchez", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México City 02990, Mexico.
Edgar Mendoza ReyesUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 3 "Dr. Víctor Manuel Espinosa de los Reyes Sánchez", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México City 02990, Mexico.
José Damián Gómez ArchillaUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 3 "Dr. Víctor Manuel Espinosa de los Reyes Sánchez", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México City 02990, Mexico.ORCID 0000-0002-9450-8731
Lucia Daniela García MontesUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 3 "Dr. Víctor Manuel Espinosa de los Reyes Sánchez", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México City 02990, Mexico.ORCID 0000-0002-5342-2421
Mauricio Ramiro Cortez ChávezUnidad Médica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 3 "Dr. Víctor Manuel Espinosa de los Reyes Sánchez", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México City 02990, Mexico.
María Isabel Peña-CanoHospital de Gineco-Obstetricia 221, Instituto Mexicano del Seguro Social, Toluca 50150, Mexico.
Renata SaucedoUnidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City 06720, Mexico.ORCID 0000-0001-5167-6156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) increases the risk of fetal overgrowth and macrosomia, yet the molecular mechanisms remain unclear. Emerging evidence implicates primate-specific placental microRNAs (miRNAs) from the C19MC cluster in modulating fetal growth via the insulin-like growth factor (IGF) axis. This study aimed to investigate the expression of circulating C19MC miRNAs in GDM pregnancies and their association with IGF axis biomarkers and birthweight outcomes. In this cross-sectional study, 158 pregnant women were stratified into normoglycemic pregnancies (

Indexed as

Circulating MicroRNADiabetes, GestationalFetal MacrosomiaMicroRNAsSomatomedinsAdultBiomarkersBirth WeightCross-Sectional StudiesFemaleHumansInfant, NewbornPregnancyBiomarkersCirculating MicroRNAMicroRNAsSomatomedinsC19MC microRNAsepigenetic regulationfetal macrosomiagestational diabetes mellitus (GDM)IGF-binding proteins (IGFBPs)insulin-like growth factor (IGF) systemplacental biomarkers

Identifiers

PMID40943286
PMCPMC12427975

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.