ArticleInternational journal of molecular sciences2025
Levels of Exhaled Fraction of Nitric Oxide (FeNO) and Type 2 Biomarkers in Individuals Naturally Exposed to Helminth Parasites in a Tropical Region.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Context-specific genetic effects inform endotypes and treatment in asthma.The Journal of allergy and clinical immunology · 2026Article
- Metabolomics-Based Analysis Linking Oxidative Stress-Related Branched-Chain Amino Acid (BCAA) Pathway with Atopic Indices to Childhood Allergies.Antioxidants (Basel, Switzerland) · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
The exhaled fraction of nitric oxide (FeNO) is a biomarker of type 2 inflammation, reflecting the activity of inducible nitric oxide synthase (iNOS) in the bronchial epithelium in response to IL-4 and IL-13. Elevated FeNO levels support asthma diagnosis; however, it is unclear whether active helminth infections and rural environments influence this biomarker. The aim of this study was to compare FeNO levels among subjects naturally infected with helminth parasites and to evaluate their correlation with eosinophil counts and other inflammatory mediators. A total of 275 adult asthmatic patients and 161 healthy controls were involved; also, 223 asthmatic children and 114 healthy controls from the urban area of Cartagena were compared to 90 healthy children from a rural area. We found significant differences in FeNO levels between asthmatic patients and healthy controls in both adult and children's cohorts (
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