Evidence map›Paper›PMID 40943256›Full record

ArticleInternational journal of molecular sciences2025

Pilot Exploratory Analysis of Serum Gonadal Hormones, Inflammatory Proteins, and Intracerebral Hemorrhage Outcomes.

Yisi Ng, Wenjing Qi, Anna Covington, Bobby Boone, Cynthia Kuhn, Andrew B Nixon, Nicolas Kon Kam King, Peter F Kranz, Thomas Christianson, Roshni Thakkar and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yisi NgDuke-NUS Medical School, Singapore 169857, Singapore.
Wenjing QiData Coordinating Center, University of Utah, Salt Lake City, UT 84112, USA.
Anna CovingtonDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.
Bobby BooneData Coordinating Center, University of Utah, Salt Lake City, UT 84112, USA.
Cynthia KuhnDuke Institute for Brain Sciences, Duke University, Durham, NC 27710, USA.
Andrew B NixonDuke Cancer Center, Duke University, Durham, NC 27710, USA.
Nicolas Kon Kam KingNeuro Asia Care, Mount Elizabeth Hospital, Singapore 228510, Singapore.
Peter F KranzDepartment of Radiology, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-5410-7135
Thomas ChristiansonDepartment of Anesthesiology, University of Tennessee, Knoxville, TN 37920, USA.
Roshni ThakkarDepartment of Anesthesiology, University of Tennessee, Knoxville, TN 37920, USA.
Daniel T LaskowitzDuke-NUS Medical School, Singapore 169857, Singapore.
Cina SasannejadDepartment of Neurology, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-6617-567X
Miran BhimaDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-9150-149X
Vijay KrishnamoorthyDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.
Shreyansh ShahDepartment of Neurology, Duke University, Durham, NC 27710, USA.
Amy K WagnerDepartment of Physical Medicine & Rehabilitation, Neuroscience, and Clinical & Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-3245-6523
Michael L JamesDuke-NUS Medical School, Singapore 169857, Singapore.ORCID 0000-0002-8715-5210

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) remains the least treatable form of stroke, with inflammation implicated as a major pathophysiological feature. Hence, this study sought to associate serum proteins and hormones associated with inflammation and ICH outcomes. Patients presenting to Duke University Hospital with computed tomography-verified spontaneous, supratentorial, non-traumatic ICH within 24 h of symptom onset were prospectively recruited. In this pilot study, equal numbers of men and women and Black and White individuals were included and matched by a 6-month modified Rankin Score (mRS). The primary analyses were the correlation of L-ratios (LR; Log2(Day 2/Day 1 concentrations)) of serum gonadal hormones and neuroinflammatory proteins with mRS > 3 at 6 months. A total of 40 participants were included in this pilot study. LRs were significantly higher for C-reactive protein (CRP;

Indexed as

Cerebral HemorrhageGonadal HormonesAgedBiomarkersC-Reactive ProteinFemaleHumansInflammationInterleukin-6MaleMiddle AgedPilot ProjectsProspective StudiesBiomarkersC-Reactive ProteinGonadal HormonesInterleukin-6antihypertensiveintracerebral hemorrhagemultiple regressionnicardipine

Identifiers

PMID40943256
PMCPMC12427954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.