Evidence map›Paper›PMID 40943242›Full record

ArticleInternational journal of molecular sciences2025

Rescue of

Divyalakshmi Soundararajan, Emi Kouyama-Suzuki, Yoshinori Shirai, Shaun Orth, Veronika Borisov, Yonat Israel, Yisrael Weiss, Leah Avi-Isaac, Niguse H Garoma, Orit Lache and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Divyalakshmi SoundararajanCenter for Translational Research in Neurodevelopmental Disease, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0009-0009-4867-9538
Emi Kouyama-SuzukiDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Yoshinori ShiraiDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-3263-4986
Shaun OrthTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.
Veronika BorisovTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.
Yonat IsraelTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.
Yisrael WeissTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.
Leah Avi-IsaacTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.
Niguse H GaromaTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.ORCID 0000-0002-2683-7285
Orit LacheTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.
Nina S LevyTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.
Suyao LiDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Weichen ZangDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Shai NetserSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 3103301, Israel.ORCID 0000-0003-4176-1124
Shlomo WagnerSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 3103301, Israel.ORCID 0000-0002-7618-0752
Gabriel JimenezCenter for Translational Research in Neurodevelopmental Disease, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Wayne N FrankelCenter for Translational Research in Neurodevelopmental Disease, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Katsuhiko TabuchiDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-1673-4637
Tristan T SandsCenter for Translational Research in Neurodevelopmental Disease, Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Andrew P LevyTechnion Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel.

Funding

GENETIC DETERMINANTS OF EPILEPSY IN MURINE SYSTEMSR01NS031348 · NINDS · JACKSON LABORATORY · PI SANDS, TRISTAN T · 1993 to 2025
$11.5M
NIH HHS RO1NS031348NINDS NIH HHS R01 NS031348
6 · The paper itself

Abstract

The IQSEC2 protein is a guanine nucleotide exchange factor for Arf6. Pathogenic variants in the X-linked

Indexed as

DependovirusGenetic TherapyGuanine Nucleotide Exchange FactorsAnimalsDisease Models, AnimalGenetic VectorsHumansMaleMiceMice, KnockoutGuanine Nucleotide Exchange FactorsIQSEC2 protein, humanadeno-associated virusautismepilepsygene therapyintellectual disabilityIQSEC2

Identifiers

PMID40943242
PMCPMC12427686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.