Evidence map›Paper›PMID 40943203›Full record

ArticleInternational journal of molecular sciences2025

Bisphenol A and Its Analogue Bisphenol S Inhibit Cholinergic Neurotransmission at the Tripartite Colonic Myenteric Synapse of CD1 Mice by Targeting Interstitial Cells of Cajal.

Krystyna Makowska, Cátia Vieira, Isabel Silva, Yoce Aprianto, Diogo Silva, Catarina Bessa-Andrês, Ana Lopes, Sławomir Gonkowski, Paulo Correia-de-Sá

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?Comprehensive reviews in food science and food safety · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Krystyna MakowskaDepartment of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-957 Olsztyn, Poland.ORCID 0000-0003-2402-6486
Cátia VieiraLaboratório de Farmacologia e Neurobiologia, Center for Drug Discovery and Innovative Medicines (MedInUP) and RISE-Health: Health Research Network, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal.
Isabel SilvaLaboratório de Farmacologia e Neurobiologia, Center for Drug Discovery and Innovative Medicines (MedInUP) and RISE-Health: Health Research Network, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal.ORCID 0000-0001-7244-4792
Yoce ApriantoLaboratório de Farmacologia e Neurobiologia, Center for Drug Discovery and Innovative Medicines (MedInUP) and RISE-Health: Health Research Network, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal.
Diogo SilvaLaboratório de Farmacologia e Neurobiologia, Center for Drug Discovery and Innovative Medicines (MedInUP) and RISE-Health: Health Research Network, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal.
Catarina Bessa-AndrêsLaboratório de Farmacologia e Neurobiologia, Center for Drug Discovery and Innovative Medicines (MedInUP) and RISE-Health: Health Research Network, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal.ORCID 0000-0002-5414-2691
Ana LopesLaboratório de Farmacologia e Neurobiologia, Center for Drug Discovery and Innovative Medicines (MedInUP) and RISE-Health: Health Research Network, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal.
Sławomir GonkowskiDepartment of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-957 Olsztyn, Poland.ORCID 0000-0002-3528-3958
Paulo Correia-de-SáLaboratório de Farmacologia e Neurobiologia, Center for Drug Discovery and Innovative Medicines (MedInUP) and RISE-Health: Health Research Network, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal.ORCID 0000-0002-6114-9189

Funding

National Science Centre 2018/31/N/NZ7/01252
6 · The paper itself

Abstract

Bisphenol A (BPA) and bisphenol S (BPS) are frequently used in the plastic industry. Despite significant alimentary exposure, their effects on the gastrointestinal (GI) tract remain largely unknown. Cholinergic and/or purinergic neurotransmission facilitates GI tract motility and secretion, indirectly controlling the absorption and toxicity of xenobiotics. Hence, this study examined the neurochemical effects of BPA and BPS in the tripartite cholinergic myenteric synapse of CD1 mice colon. Short time exposure to both bisphenols showed a partial loss of VAChT-positive neurons and Ano-1-positive interstitial cells of Cajal (ICCs), without affecting the amount of glial cells labelled with S100β. Both bisphenols reduced the spontaneous myographic activity and the release of [

Indexed as

Benzhydryl CompoundsColonInterstitial Cells of CajalMyenteric PlexusPhenolsSulfonesSynaptic TransmissionAcetylcholineAnimalsBisphenol A CompoundsBisphenol S CompoundsMaleMiceNeuronsAcetylcholineBenzhydryl Compoundsbisphenol ABisphenol A Compoundsbisphenol SBisphenol S CompoundsPhenolsSulfonesbisphenolcolonenteric nervous systemmicemyenteric synapse

Identifiers

PMID40943203
PMCPMC12428379

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.