Evidence map›Paper›PMID 40943197›Full record

ReviewInternational journal of molecular sciences2025

MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.

Gyutae Choi, Sanghyo Lee, Seungjae Yoo, Jeung Tae Do

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. A novel heterozygous pathogenic variation in theTranslational pediatrics · 2026
    Article
  7. Review
  8. The Role of mRNA Alternative Processing in Mammalian Neurodevelopment.International journal of molecular sciences · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gyutae ChoiDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Technology, Konkuk University, Seoul 05029, Republic of Korea.ORCID 0009-0007-0416-4036
Sanghyo LeeDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Technology, Konkuk University, Seoul 05029, Republic of Korea.ORCID 0009-0004-7826-7423
Seungjae YooDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Technology, Konkuk University, Seoul 05029, Republic of Korea.
Jeung Tae DoDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Technology, Konkuk University, Seoul 05029, Republic of Korea.ORCID 0000-0001-6721-1441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rett syndrome is a severe neurodevelopmental disorder that occurs primarily in females and is caused by mutations in the methyl-CpG-binding protein 2 (

Indexed as

Methyl-CpG-Binding Protein 2Rett SyndromeAnimalsCentral Nervous SystemEpigenesis, GeneticHumansMutationNeurotransmitter AgentsX ChromosomeMethyl-CpG-Binding Protein 2Neurotransmitter AgentsAAV gene therapyepigeneticsglial pathologyMECP2neuronal dysfunctionRett syndrometranscriptional regulationX chromosome inactivation

Identifiers

PMID40943197
PMCPMC12428351

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.