Evidence map›Paper›PMID 40943091›Full record

ArticleInternational journal of molecular sciences2025

Regioselective Synthesis of 5-Substituted 3-(β-d-Glycopyranosyl)isoxazoles and -isoxazolines by 1,3-Dipolar Cycloaddition as Potential Anticancer Agents and Glycogen Phosphorylase Inhibitors.

Tímea Kaszás, Bence Szakács, Márta Bertalan, Tekla Blága, Faria Hameed, Ákos Lengyel, Samreen Saifi, Éva Juhász-Tóth, Luca A Varga, Tibor Docsa and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Synthesis of mono- and di-(Frontiers in chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tímea KaszásDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Bence SzakácsDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.ORCID 0000-0002-9157-3028
Márta BertalanDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Tekla BlágaDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Faria HameedDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Ákos LengyelDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Samreen SaifiDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Éva Juhász-TóthDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Luca A VargaDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Tibor DocsaDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Adrienn SiposDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.ORCID 0009-0002-9713-0639
Péter BaiDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.ORCID 0000-0002-6191-6616
Anita ÁbrahámDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
Attila Kiss-SzikszaiDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.ORCID 0000-0003-3601-5143
Sándor KunDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.ORCID 0000-0002-0111-390X
György Attila KissDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
János JózsefDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.
László JuhászDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.ORCID 0000-0002-7462-7944
Marietta TóthDepartment of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary.ORCID 0000-0002-4624-038X

Funding

Bolyai Fellowship of the Hungarian Academy of Sciences (to A.S.)HUN-REN Hungarian Research NetworkNational Research, Development and Innovation Fund of Hungary TKP2021-EGA: TKP2021-EGA-19 and TKP2021-EGA-20National Research, Development and Innovation Office of Hungary FK 146852 (to A.S.)National Research, Development and Innovation Office of Hungary K142141 (to P.B.)National Research, Development and Innovation Office of Hungary PD 142641 (to T.K.)University of Debrecen Program for Scientific Publication
6 · The paper itself

Abstract

Anhydro-aldose oximes were employed to generate in situ nitrile oxides via a halogenation/base-induced elimination sequence in the presence of NCS and Et

Indexed as

Antineoplastic AgentsEnzyme InhibitorsGlycogen PhosphorylaseIsoxazolesCell Line, TumorCycloaddition ReactionFemaleHumansAntineoplastic AgentsEnzyme InhibitorsGlycogen PhosphorylaseIsoxazoles1,3-dipolar cycloaddition3-(β-d-glycopyranosyl)isoxazole3-(β-d-glycopyranosyl)isoxazolineanhydro-aldose oximeanticancer activityglycogen phosphorylase inhibitionnitrile oxides

Identifiers

PMID40943091
PMCPMC12427784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.