Evidence map›Paper›PMID 40943056›Full record

ArticleInternational journal of molecular sciences2025

Transcriptomic Identification of Immune-Related Hubs as Candidate Predictor Biomarkers of Therapeutic Response in Psoriasis.

Elisabet Cantó, María Elena Del Prado, Eva Vilarrasa, Anna López-Ferrer, Francisco Javier García Latasa de Araníbar, Maria Angels Ortiz, Marta Gut, Maria Mulet, Anna Esteve-Codina, Ruben Osuna-Gómez and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisabet CantóGroup of Inflammatory Diseases, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain.
María Elena Del PradoDermatology Unit, Hospital Quirónsalud, 50012 Zaragoza, Spain.
Eva VilarrasaDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.
Anna López-FerrerDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.ORCID 0000-0002-2121-963X
Francisco Javier García Latasa de AraníbarDermatology Unit, Hospital Royo Villanova, 50015 Zaragoza, Spain.
Maria Angels OrtizGroup of Inflammatory Diseases, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain.ORCID 0000-0002-1574-9861
Marta GutCentro Nacional de Analisis Genomico (CNAG), 08028 Barcelona, Spain.ORCID 0000-0002-4063-7159
Maria MuletGroup of Inflammatory Diseases, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain.ORCID 0000-0003-3639-3291
Anna Esteve-CodinaCentro Nacional de Analisis Genomico (CNAG), 08028 Barcelona, Spain.ORCID 0000-0003-0361-2873
Ruben Osuna-GómezGroup of Inflammatory Diseases, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain.ORCID 0000-0003-2875-4405
Albert Guinart-CuadraGroup of Inflammatory Diseases, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain.ORCID 0000-0003-0233-5595
Luís PuigDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.ORCID 0000-0001-6083-0952
Silvia VidalGroup of Inflammatory Diseases, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain.ORCID 0000-0002-3909-6682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a chronic inflammatory skin disease driven by genetic, environmental, and immune factors. While biologics like adalimumab (anti-TNFα) and risankizumab (anti-IL-23) have improved outcomes, patient response variability remains unclear. This study examined immune-related transcriptomic differences between lesional (L) and non-lesional (NL) psoriatic skin, focusing on immune-related hub genes, their plasma levels, and their correlations with severity and treatment response. Patients with moderate-to-severe psoriasis were enrolled before treatment with anti-TNFα (

Indexed as

PsoriasisTranscriptomeAdalimumabAdultBiomarkersChemokine CCL20FemaleGene Expression ProfilingHumansInterleukin-23Interleukin-6Interleukin-8MaleMiddle AgedProtein Interaction MapsSeverity of Illness IndexAdalimumabBiomarkersCCL20 protein, humanChemokine CCL20Interleukin-23Interleukin-6Interleukin-8Tumor Necrosis Factor-alphabiomarkershubsinflammationpsoriasistranscriptomic

Identifiers

PMID40943056
PMCPMC12427958

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.